One-Pot Synthesis of Diazine-Bridged Bisindoles and Concise Synthesis of the Marine Alkaloid Hyrtinadine A

被引：37

作者：

Tasch, Boris O. A. ^{[1
]}

Merkul, Eugen ^{[1
]}

Mueller, Thomas J. J. ^{[1
]}

机构：

[1] Univ Dusseldorf, Inst Organ Chem & Makromol Chem, D-40225 Dusseldorf, Germany

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 2011卷 / 24期

关键词：

Alkaloids; Arylation; Boron; C-C coupling; Multicomponent reactions; Palladium; PALLADIUM-CATALYZED BORYLATION; CROSS-COUPLING REACTIONS; 3-COMPONENT SYNTHESIS; INDOLE ALKALOIDS; ARYL HALIDES; ACID; BIS; DIALKOXYBORANE; HYDROCHLORIDE; 3-HALOFURANS;

D O I：

10.1002/ejoc.201100680

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Diazine-bridged bisindoles are readily obtained from N-Boc-protected 3-iodoindoles and 3-iodo-7-azaindole in a pseudo three-component reaction involving a one-pot Masuda borylation-Suzuki arylation sequence. Some of the title compounds display promising cytotoxic properties. The versatility of this methodology is illustrated by a very concise total synthesis of the marine alkaloid hyrtinadine A.

引用

页码：4532 / 4535

页数：4

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