Research on the antioxidant, wound healing, and anti-inflammatory activities and the phytochemical composition of maritime pine (Pinus pinaster Ait)

被引：70
作者：
Tumen, Ibrahim [1 ,2 ]
Akkol, Esra Kupeli [3 ]
Tastan, Hakki [4 ]
Suntar, Ipek [3 ]
Kurtca, Mehmet [2 ]
机构：
[1] Bartin Univ, Fac Forestry, Dept Forest Prod Chem, TR-74100 Bartin, Turkey
[2] Bartin Univ, Vocat Sch Hlth Serv, TR-74100 Bartin, Turkey
[3] Gazi Univ, Fac Pharm, Dept Pharmacognosy, TR-06330 Ankara, Turkey
[4] Gazi Univ, Fac Sci, Dept Biol, TR-06330 Ankara, Turkey
来源：
JOURNAL OF ETHNOPHARMACOLOGY | 2018年 / 211卷
关键词：
Essential oil; Inflammation; Martime pine; Pinaceae; Pinus pinaster; Wound; ESSENTIAL OILS; BARK EXTRACT; NEUTROPHIL ELASTASE; INHIBITION; L; PYCNOGENOL((R)); LEAVES; MICE; METALLOPROTEINASES; FORMULATIONS;
D O I：
10.1016/j.jep.2017.09.009
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Ethnopharmacological relevance: Ethnobotanical investigations have shown that the Pious species have been used against rheumatic pain and for wound healing in Turkish folk medicine. Material and methods: In this study, phytochemical composition, antioxidant, anti-inflammatory, and wound healing activities of Maritime Pine (Pious pinaster Ait.) that is collected in Turkey are investigated. Essential oil composition and the amount of extracts (lipophilic and hydrophilic) of maritime pine wood and fresh cone samples had been tested. Results: The essential oil from cones of P. pinaster revealed the highest activities, whereas other parts of the plant did not display any appreciable wound healing, anti-inflammatory, or antioxidant effects. a-Pinene was the main constituent of the essential oil obtained from the cones of P. pinaster. Conclusion: Experimental studies shown that P. pinaster's remarkable anti-inflammatory and wound healing activities support the traditional use of the plant, and suggest it could have a place in modern medicine.
引用
收藏
页码：235 / 246
页数：12
相关论文
共 64 条
[1]  
Adams R.P., 2007, Allured publishing corporation Carol Stream, V4th
[2]   Thuja occidentalis L. and its active compound, α-thujone: Promising effects in the treatment of polycystic ovary syndrome without inducing osteoporosis [J].
Akkol, Esra Kupeli ;
Ilhan, Mert ;
Demirel, Murside Ayse ;
Keles, Hikmet ;
Tumen, Ibrahim ;
Suntar, Ipek .
JOURNAL OF ETHNOPHARMACOLOGY, 2015, 168 :25-30
[3]   The potential role of female flowers inflorescence of Typha domingensis Pers. in wound management [J].
Akkol, Esra Kupeli ;
Suntar, Ipek ;
Keles, Hikmet ;
Yesilada, Erdem .
JOURNAL OF ETHNOPHARMACOLOGY, 2011, 133 (03) :1027-1032
[4]   The hydrophilic and lipophilic contribution to total antioxidant activity [J].
Arnao, MB ;
Cano, A ;
Acosta, M .
FOOD CHEMISTRY, 2001, 73 (02) :239-244
[5]   Composition of the essential oils from leaves, branches and cones of Pinus laricio Poiret collected in Sicily, Italy [J].
Bader, A ;
Flamini, G ;
Cioni, PL ;
Morelli, I .
JOURNAL OF ESSENTIAL OIL RESEARCH, 2000, 12 (06) :672-674
[6]  
Barnola LF, 2000, BIOCHEM SYST ECOL, V28, P923, DOI 10.1016/S0305-1978(00)00036-3
[7]   Inhibition of collagenase and metalloproteinases by aloins and aloe gel [J].
Barrantes, E ;
Guinea, M .
LIFE SCIENCES, 2003, 72 (07) :843-850
[8]   Pycnogenol inhibits generation of inflammatory mediators in macrophages [J].
Bayeta, E ;
Lau, BHS .
NUTRITION RESEARCH, 2000, 20 (02) :249-259
[9]   Treatment of osteoarthritis with Pycnogenol®.: The SVOS (San!Valentino osteo-arthrosis study).: Evaluation of signs, symptoms, physical performance and vascular aspects [J].
Belcaro, G. ;
Cesarone, M. R. ;
Errichi, S. ;
Zulli, C. ;
Errichi, B. M. ;
Vinciguerra, G. ;
Ledda, A. ;
Di Renzo, A. ;
Stuard, S. ;
Dugall, M. ;
Pellegrini, L. ;
Errichi, S. ;
Gizzi, G. ;
Ippolito, E. ;
Ricci, A. ;
Cacchio, M. ;
Cipollone, G. ;
Ruffini, I. ;
Fano, F. ;
Hosoi, M. ;
Rohdewald, P. .
PHYTOTHERAPY RESEARCH, 2008, 22 (04) :518-523
[10]   The ferric reducing ability of plasma (FRAP) as a measure of ''antioxidant power'': The FRAP assay [J].
Benzie, IFF ;
Strain, JJ .
ANALYTICAL BIOCHEMISTRY, 1996, 239 (01) :70-76
1234567