The Role of Shugoshin in Meiotic Chromosome Segregation

被引：41

作者：

Clift, D. ^{[1
]}

Marston, A. L. ^{[1
]}

机构：

[1] Univ Edinburgh, Wellcome Trust Ctr Cell Biol, Sch Biol Sci, Edinburgh EH8 3JR, Midlothian, Scotland

来源：

CYTOGENETIC AND GENOME RESEARCH | 2011年 / 133卷 / 2-4期

基金：

英国惠康基金;

关键词：

Chromosome Segregation; Cohesin; Meiosis; PP2A; Separase; Shugoshin; SISTER-CHROMATID COHESION; PROTEIN PHOSPHATASE 2A; MEIOSIS-I; FISSION-YEAST; CENTROMERIC COHESION; AURORA-B; REC8; PHOSPHORYLATION; DROSOPHILA MEI-S332; INNER CENTROMERE; MAMMALIAN SGO2;

D O I：

10.1159/000323793

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

During meiosis, DNA replication is followed by 2 successive chromosome segregation events, resulting in the production of gametes with a haploid number of chromosomes from a diploid precursor cell. Faithful chromosome segregation in meiosis requires that sister chromatid cohesion is lost from chromosome arms during meiosis I, but retained at centromeric regions until meiosis II. Recent studies have begun to uncover the mechanisms underlying this stepwise loss of cohesion in meiosis and the role of a conserved protein, shugoshin, in regulating this process. Copyright (C) 2011 S. Karger AG, Basel

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收藏

页码：234 / 242

页数：9

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