Metabolome Analysis Reveals Potential Mechanisms of Mannan Oligosaccharides to Improve Health, Growth Performance, and Fatty Acid Deposition in Hu Lambs

被引:6
|
作者
Liu, Ting [1 ]
Li, Fadi [2 ,3 ]
Xu, Jianfeng [1 ]
Wang, Jing [1 ]
Shen, Zhenfeng [1 ]
Zhang, Fan [1 ]
Wang, Jiaqi [1 ]
Zheng, Chen [1 ]
机构
[1] Gansu Agr Univ, Coll Anim Sci & Technol, Lanzhou 730070, Peoples R China
[2] Lanzhou Univ, Coll Pastoral Agr Sci & Technol, Key Lab Grassland Livestock Ind Innovat, Minist Agr & Rural Affairs,State Key Lab Grasslan, Lanzhou 730020, Peoples R China
[3] Engn Lab Mutton Sheep Breeding & Reprod Biotechno, Minqin 733300, Peoples R China
来源
AGRICULTURE-BASEL | 2022年 / 12卷 / 09期
基金
中国国家自然科学基金;
关键词
fatty acid; growth performance; lamb; mannan oligosaccharides; metabolites; metabolome; MEAT QUALITY; NUTRIENT DIGESTIBILITY; FED DIETS; FEED; MILK; SUPPLEMENTATION; DIARRHEA; FORAGE; CALVES;
D O I
10.3390/agriculture12091327
中图分类号
S3 [农学(农艺学)];
学科分类号
0901 ;
摘要
The effect of mannan oligosaccharides (MOS) on health, growth performance, fatty acids deposition, serum, and urine metabolites, as well as the correlation between differential metabolites and other indexes, were investigated in Hu lambs. In total, 30 seven-day-old Hu male lambs were fed a milk replacer with or without 0.2% MOS (15 lambs in each). The lambs were placed on this diet until they were 28 days old. MOS significantly increased the apparent digestibility of organic matter (OM), crude protein (CP), ether extract (EE), calcium (Ca) and phosphorus (P), and unsaturated fatty acid (UFA) proportion, and decreased the diarrhea rate and saturated fatty acid (SFA) proportion in lambs (p < 0.05). MOS upregulated 20 metabolites in serum and 1 in urine and downregulated 11 metabolites in serum and 2 in urine (p < 0.05). Most of these metabolites comprised glycerophosphoethanolamines and glycerophosphocholines, which are significantly correlated with nutrient digestibility and fatty acid composition (p < 0.05). Overall, our results suggest that MOS benefited the health, nutrient utilization, and fatty acid profiles in Hu lambs via glycerolipid and glycerophospholipid metabolism pathways.
引用
收藏
页数:19
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