Improvement in colorectal cancer survival: A population-based study

被引：73
作者：
Mitry, E
Bouvier, AM
Esteve, J
Faivre, J
机构：
[1] Fac Med, Registre Canc Digestifs, F-21079 Dijon, France
[2] Univ Versailles, AP HP, Hop Ambroise Pare, Serv Hepatogastroenterol & Oncol Digest, F-92100 Boulogne, France
[3] Ctr Hosp Lyon Sud, Lab Biostat & Modelisat Epidemiol & Rech Clin, F-69445 Pierre Benite, France
来源：
EUROPEAN JOURNAL OF CANCER | 2005年 / 41卷 / 15期
关键词：
aged; colorectal neoplasms; epidemiology; prognosis; registries; survival;
D O I：
10.1016/j.ejca.2005.01.028
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The aim of this study was to explore the reasons for improvement in colorectal cancer survival. Trends in relative survival among 5874 patients diagnosed with colorectal cancer over a 24-year period in a well-defined French population were analysed. The 5-year relative survival rate, excluding operative mortality, increased from 49.2% to 56.3% between the periods 1976-1987 and 1988-1999. In multivariate analysis, stage at diagnosis and adjuvant chemotherapy were both associated with better survival after surgery with curative intent. Survival trends differed markedly by age. The improvement in overall survival for older patients can be attributed to the increase in the proportion of patients resected for cure. For younger patients, there was an increase in the proportion of patients operated for cure, but also an improvement in stage-specific survival, particularly for stage III tumours, suggesting an impact of adjuvant chemotherapy. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2297 / 2303
页数：7
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