The rise and fall of compartmental analysis

被引：19
作者：
Rescigno, A
机构：
[1] Stillwater, MN 55082-9278
来源：
PHARMACOLOGICAL RESEARCH | 2001年 / 44卷 / 04期
关键词：
compartmental models; physiological models; AUC; AUMC; tracer kinetics; residence time; exit time; volume of distribution;
D O I：
10.1006/phrs.2001.0873
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The concept of compartment evolved in the contexts of radioactivity, physiology, pharmacology and tracer kinetics. Recently compartmental models have been compared with 'physiological models', C even though in most cases the same, or stricter hypotheses, are necessary for the validity of these latter models. This paper shows that the methods of compartmental analysis are valid only if some specific hypotheses are valid. (C) 2001 Academic Press.
引用
收藏
页码：337 / 342
页数：6
相关论文
共 27 条
[1]  
ARTOM C., 1938, ARCH INTERNAT PHYSIOL, V47, P245, DOI 10.3109/13813453809148721
[2]  
Becquerel H., 1896, Comptes Rendus de l'Academie des Sciences, V122, P420
[3]  
Becquerel Henri, 1896, CR HEBD ACAD SCI, V122, P420
[4]   The rate of elimination of dissolved nitrogen in man in relation to the fat and water content of the body [J].
Behnke, AR ;
Thomson, RM ;
Shaw, LA .
AMERICAN JOURNAL OF PHYSIOLOGY, 1935, 114 (01) :137-146
[5]   MEAN RESIDENCE TIME IN THE BODY VERSUS MEAN RESIDENCE TIME IN THE CENTRAL COMPARTMENT [J].
BENET, LZ .
JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS, 1985, 13 (05) :555-558
[6]  
BERGNER P E, 1962, Acta Radiol Suppl, V210, P1
[7]  
BERMAN M, 1972, METHODS INVESTIGATIV
[8]   NOMENCLATURE FOR TRACER KINETICS [J].
BROWNELL, GL ;
BERMAN, M ;
ROBERTSON, JS .
INTERNATIONAL JOURNAL OF APPLIED RADIATION AND ISOTOPES, 1968, 19 (03) :249-+
[9]   MULTIEXPONENTIAL, MULTICOMPARTMENTAL, AND NONCOMPARTMENTAL MODELING .1. METHODOLOGICAL LIMITATIONS AND PHYSIOLOGICAL INTERPRETATIONS [J].
DISTEFANO, JJ ;
LANDAW, EM .
AMERICAN JOURNAL OF PHYSIOLOGY, 1984, 246 (05) :R651-R664
[10]  
GURPIDE E, 1975, TRACER METHODS HORMO
123