Synthesis of Fluorescent Silica Nanoparticles and Their Applications as Fluorescence Probes

被引：22

作者：

Song, Xu ^{[1
]}

Li, Fang ^{[2
]}

Ma, Jingwei ^{[3
]}

Jia, Nengqin ^{[1
]}

Xu, Jianming ^{[4
]}

Shen, Hebai ^{[1
]}

机构：

[1] Shanghai Normal Univ, Dept Chem, Shanghai 200234, Peoples R China

[2] Tongji Univ, Sch Med, Shanghai Matern & Infant Hosp 1, Shanghai 200040, Peoples R China

[3] Shanghai BaiHuiShen Biosci & Tech Co Ltd, Shanghai 200030, Peoples R China

[4] Fudan Univ, Sch Med, Zhongshan Hosp, Shanghai 200030, Peoples R China

来源：

JOURNAL OF FLUORESCENCE | 2011年 / 21卷 / 03期

关键词：

Fluorescent silica nanoparticles; Luminescence; Fluorescent probe; Cellular imaging; QUANTUM DOTS; NANOSPHERES; PARTICLES; GROWTH; CELLS;

D O I：

10.1007/s10895-010-0799-6

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

This paper presents the synthesis of organic dye molecules embedded silica nanoparticles by Stober method and their applications as fluorescence probes in cell imaging. By modifying the surface of fluorescent silica nanoparticles (FSNs) with amino, biologically functionalized and monodisperse FSNs can be obtained. In this work, FSNs were conjugated with monoclonal anti-Carcinoembryonic Antigen (anti-CEA) antibody via covalent binding. The antibody-conjugated FSNs can be used to label the SPCA-1 cells successfully, demonstrating that the application of FSNs as fluorescence probes in fluorescence imaging and bioassay would be feasible.

引用

页码：1205 / 1212

页数：8

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