An insertion-deletion polymorphism in angiotensin-converting enzyme is associated with a reduced risk of preeclampsia: an evidence-based meta-analysis from 44 studies

被引：4

作者：

Huang, Ting ^{[1
]}

Yan, Yu ^{[1
]}

Li, Jianxin ^{[1
]}

Chen, Hong ^{[1
]}

Chen, Zhen ^{[1
]}

机构：

[1] Chongqing Hlth Ctr Women & Children, Dept Obstet, Chongqing, Peoples R China

来源：

HYPERTENSION IN PREGNANCY | 2020年 / 39卷 / 03期

关键词：

Angiotensin-converting enzyme; polymorphism; preeclampsia; meta-analysis; GENE POLYMORPHISMS; BLOOD-PRESSURE; ESSENTIAL-HYPERTENSION; I/D POLYMORPHISM; ACE-I/D; RENIN; PREGNANCY; LINKAGE; SYSTEM; PREDISPOSITION;

D O I：

10.1080/10641955.2020.1769644

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective An updated meta-analysis was performed to evaluate the relationship between an insertion/deletion (I/D) polymorphism in angiotensin-converting enzyme (ACE) and preeclampsia (PE) risk. Methods Pubmed, OVID and China National Knowledge Infrastructure databases were searched. Pooled odds ratios with 95% confidence intervals were calculated using fixed-effects or random-effects model. ResultsACE I/D polymorphism decreased the risk of PE in overall analysis. Subgroup analysis revealed a significantly lower risk of PE withACE I/Dpolymorphism in Asians, Caucasians. The decreased risk was also found in severe PE and early-onset PE. ConclusionACE I/D polymorphism may protect against the development of PE.

引用

页码：336 / 347

页数：12

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