Novel Pharmacotherapy for Hypertrophic Cardiomyopathy

被引：1
作者：
Wong, Timothy C. [1 ]
Martinez, Matthew [2 ]
机构：
[1] Univ Pittsburgh, Sch Med, UPMC Hypertroph Cardiomyopathy Ctr, Dept Med,Div Cardiol,UPMC Heart & Vasc Inst, 200 Lothrop St, Pittsburgh, PA 15213 USA
[2] Lehigh Valley Hlth Network, Div Cardiol, 1250 South Cedar Crest Blvd,Suite 300, Allentown, PA 18103 USA
来源：
CARDIOLOGY CLINICS | 2019年 / 37卷 / 01期
关键词：
Hypertrophic cardiomyopathy; Medical therapy; Clinical trials; Novel drug development; VENTRICULAR DIASTOLIC FUNCTION; CARDIAC-HYPERTROPHY; TASK-FORCE; HEART; ALDOSTERONE; DYSFUNCTION; INHIBITION; MANAGEMENT; DIAGNOSIS; MODULATOR;
D O I：
10.1016/j.ccl.2018.08.008
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Medical therapy for hypertrophic cardiomyopathy (HCM) has focused on minimizing the impact of symptoms due to left ventricular outflow tract obstruction and diastolic dysfunction. This article briefly discusses currently available therapy and focuses on both clinically available medications with novel applications for HCM as well as novel medications under development with specific indication for HCM. Finally, a brief summary of the current gaps and potential targets for pharmacotherapy is discussed.
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页码：113 / +
页数：6
相关论文
共 35 条
  • [1] Metabolic Modulator Perhexiline Corrects Energy Deficiency and Improves Exercise Capacity in Symptomatic Hypertrophic Cardiomyopathy
    Abozguia, Khalid
    Elliott, Perry
    McKenna, William
    Phan, Thanh Trung
    Nallur-Shivu, Ganesh
    Ahmed, Ibrar
    Maher, Abdul R.
    Kaur, Kulvinder
    Taylor, Jenny
    Henning, Anke
    Ashrafian, Houman
    Watkins, Hugh
    Frenneaux, Michael
    [J]. CIRCULATION, 2010, 122 (16) : 1562 - U56
  • [2] Effect of Losartan on left ventricular diastolic function in patients with nonobstructive hypertrophic cardiomyopathy
    Araujo, AQ
    Arteaga, E
    Ianni, BM
    Buck, PC
    Rabello, R
    Mady, C
    [J]. AMERICAN JOURNAL OF CARDIOLOGY, 2005, 96 (11) : 1563 - 1567
  • [3] Ranolazine Prevents Phenotype Development in a Mouse Model of Hypertrophic Cardiomyopathy
    Coppini, Raffaele
    Mazzoni, Luca
    Ferrantini, Cecilia
    Gentile, Francesca
    Pioner, Jose Manuel
    Laurino, Annunziatina
    Santini, Lorenzo
    Bargelli, Valentina
    Rotellini, Matteo
    Bartolucci, Gianluca
    Crocini, Claudia
    Sacconi, Leonardo
    Tesi, Chiara
    Belardinelli, Luiz
    Tardiff, Jil
    Mugelli, Alessandro
    Olivotto, Iacopo
    Cerbai, Elisabetta
    Poggesi, Corrado
    [J]. CIRCULATION-HEART FAILURE, 2017, 10 (03)
  • [4] Late Sodium Current Inhibition Reverses Electromechanical Dysfunction in Human Hypertrophic Cardiomyopathy
    Coppini, Raffaele
    Ferrantini, Cecilia
    Yao, Lina
    Fan, Peidong
    Del Lungo, Martina
    Stillitano, Francesca
    Sartiani, Laura
    Tosi, Benedetta
    Suffredini, Silvia
    Tesi, Chiara
    Yacoub, Magdi
    Olivotto, Iacopo
    Belardinelli, Luiz
    Poggesi, Corrado
    Cerbai, Elisabetta
    Mugelli, Alessandro
    [J]. CIRCULATION, 2013, 127 (05) : 575 - +
  • [5] Effect of trimetazidine and verapamil on the cardiomyopathic hamster myosin phenotype
    D'hahan, N
    Taouil, K
    Janmot, C
    Morel, JE
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 1998, 123 (04) : 611 - 616
  • [6] 2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy The Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC)
    Elliott, Perry M.
    Anastasakis, Aris
    Borger, Michael A.
    Borggrefe, Martin
    Cecchi, Franco
    Charron, Philippe
    Hagege, Albert Alain
    Lafont, Antoine
    Limongelli, Giuseppe
    Mahrholdt, Heiko
    McKenna, William J.
    Mogensen, Jens
    Nihoyannopoulos, Petros
    Nistri, Stefano
    Pieper, Petronella G.
    Pieske, Burkert
    Rapezzi, Claudio
    Rutten, Frans H.
    Tillmanns, Christoph
    Watkins, Hugh
    [J]. EUROPEAN HEART JOURNAL, 2014, 35 (39) : 2733 - +
  • [7] Research Priorities in Hypertrophic Cardiomyopathy Report of a Working Group of the National Heart, Lung, and Blood Institute
    Force, Thomas
    Bonow, Robert O.
    Houser, Steven R.
    Solaro, R. John
    Hershberger, Ray E.
    Adhikari, Bishow
    Anderson, Mark E.
    Boineau, Robin
    Byrne, Barry J.
    Cappola, Thomas P.
    Kalluri, Raghu
    LeWinter, Martin M.
    Maron, Martin S.
    Molkentin, Jeffery D.
    Ommen, Steve R.
    Regnier, Michael
    Tang, W. H. Wilson
    Tian, Rong
    Konstam, Marvin A.
    Maron, Barry J.
    Seidman, Christine E.
    [J]. CIRCULATION, 2010, 122 (11) : 1130 - 1133
  • [8] FUNCK F, 1988, ARCH MAL COEUR VAISS, V81, P525
  • [9] Ranolazine for Treatment of Angina or Dyspnea in Hypertrophic Cardiomyopathy Patients (RHYME)
    Gentry, James L., III
    Mentz, Robert J.
    Hurdle, Melissa
    Wang, Andrew
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2016, 68 (16) : 1815 - 1817
  • [10] 2011 ACCF/AHA Guideline for the Diagnosis and Treatment of Hypertrophic Cardiomyopathy A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines
    Gersh, Bernard J.
    Maron, Barry J.
    Bonow, Robert O.
    Dearani, Joseph A.
    Fifer, Michael A.
    Link, Mark S.
    Naidu, Srihari S.
    Nishimura, Rick A.
    Ommen, Steve R.
    Rakowski, Harry
    Seidman, Christine E.
    Towbin, Jeffrey A.
    Udelson, James E.
    Yancy, Clyde W.
    [J]. CIRCULATION, 2011, 124 (24) : E783 - U84
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