Automated radiosynthesis of the adenosine A2A receptor-targeting radiotracer [18F]FLUDA

被引：3

作者：

Lai, Thu Hang ^{[1
,2
]}

Wenzel, Barbara ^{[1
]}

Moldovan, Rares-Petru ^{[1
]}

Brust, Peter ^{[1
]}

Kopka, Klaus ^{[1
,3
]}

Teodoro, Rodrigo ^{[1
]}

机构：

[1] Helmholtz Zentrum Dresden Rossendorf, Dept Neuroradiopharmaceut, Inst Radiopharmaceut Canc Res, Leipzig, Germany

[2] ROTOP Pharmaka GmbH, Dept Res & Dev, Dresden, Germany

[3] Tech Univ Dresden, Fac Chem & Food Chem, Sch Sci, Dresden, Germany

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2022年 / 65卷 / 06期

关键词：

F-18]FLUDA; adenosine A(2A) receptor; automation; fluorine-18; PET; radiosynthesis; TRACERlab FX2 N;

D O I：

10.1002/jlcr.3970

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

[F-18]FLUDA is a selective radiotracer for in vivo imaging of the adenosine A(2A) receptor (A(2A)R) by positron emission tomography (PET). Promising preclinical results obtained by neuroimaging of mice and piglets suggest the translation of [F-18]FLUDA to human PET studies. Thus, we report herein a remotely controlled automated radiosynthesis of [F-18]FLUDA using a GE TRACERlab FX2 N radiosynthesizer. The radiotracer was obtained by a one-pot two-step radiofluorination procedure with a radiochemical yield of 9 +/- 1%, a radiochemical purity of >= 99%, and molar activities in the range of 69-333 GBq/mu mol at the end of synthesis within a total synthesis time of approx. 95 min (n = 16). Altogether, we successfully established a reliable and reproducible procedure for the automated production of [F-18]FLUDA.

引用

页码：162 / 166

页数：5

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