Brief social isolation in early adolescence affects reversal learning and forebrain BDNF expression in adult rats

被引:64
作者
Han, Xiao [1 ]
Wang, Weiwen [2 ]
Xue, Xiaofang [1 ]
Shao, Feng [1 ]
Li, Nanxin [1 ,3 ]
机构
[1] Peking Univ, Dept Psychol, Beijing 100871, Peoples R China
[2] Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
[3] Yale Univ, Dept Psychol, New Haven, CT 06520 USA
关键词
Adolescence; BDNF; Hippocampus; Morris water maze; Nucleus accumbens; Prefrontal cortex; Reversal learning; Social isolation; MEDIAL PREFRONTAL CORTEX; BEHAVIORAL FLEXIBILITY; DORSOMEDIAL STRIATUM; NEUROTROPHIC FACTOR; NUCLEUS-ACCUMBENS; RECEPTOR TRKB; BRAIN; LESIONS; PLASTICITY; HIPPOCAMPUS;
D O I
10.1016/j.brainresbull.2011.07.008
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Isolation rearing produces significant behavioral and neurochemical dysregulations in rodents. However, few studies have examined the effects of short-term isolation rearing during puberty compared to chronic social isolation from weaning to adulthood. In this study, we subjected weaning rats to a brief two-week social isolation and then re-socialized them until adulthood. We found that early isolation rearing affected reversal learning without interfering with spatial learning in the Morris water maze. We also found that brain-derived neurotrophic factor (BDNF) protein expression was increased in the medial prefrontal cortex (mPFC) but was decreased in the nucleus accumbens (NAc), CA1 and dentate gyrus of the hippocampus in isolation-reared rats. Together, our findings support the use of adolescent social isolation as a rodent model to study brain and behavior abnormalities induced by early environmental interruptions. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码:173 / 178
页数:6
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