Effects of artificial tears on rabbit ocular surface healing after exposure to benzalkonium chloride

被引：6

作者：

Zhang, Yuqiu ^{[1
]}

Cao, Hong ^{[2
]}

Lin, Tong ^{[1
]}

Gong, Lan ^{[1
]}

机构：

[1] Fudan Univ, Eye & ENT Hosp, Dept Ophthalmol, 83 Fenyang Rd, Shanghai 200031, Peoples R China

[2] Fudan Univ, Eye & ENT Hosp, Dept Nursing, Shanghai, Peoples R China

来源：

DRUG AND CHEMICAL TOXICOLOGY | 2016年 / 39卷 / 04期

关键词：

Benzalkonium chloride; artificial tear; rabbit; corneal disease; treatment outcome; GELLABLE LUBRICANT EYE; MODERATE DRY EYE; HYDROXYPROPYL-GUAR; HYALURONIC-ACID; HP-GUAR; OPEN-LABEL; DROPS; MEDICATIONS; POPULATION; EFFICACY;

D O I：

10.3109/01480545.2016.1146293

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The aim of the study was to observe the effect of different artificial tears on healing the drug-induced keratopathy. To this aim, 64 rabbits received topical administration of 0.01% benzalkonium chloride to establish models and were divided into four groups. The control group received ocular saline solution (Saline), while the others were treated with Refresh Plus (R) (RF), Hycosan (R) (H) and Systane (R) Ultra (SU). Surface abnormalities were examined daily using slit-lamp. Fluorescein staining, histopathological and transmission electron microscopic (TEM) examination were performed at day 0, 2 weeks, and 1 and 2 months. A significant difference was observed between RF and SU, but not between H and SU at 2 weeks. TEM examination revealed new microvilli close to the cavity surface, and the number of microvilli in SU was greater than in H at 2 weeks and 1 month. Based on the results, the effect in the SU group was the most significant. Eye drops with nontoxic preservative such as SU are an alternative to treat drug-induced keratopathy.

引用

页码：455 / 460

页数：6

共 25 条

[1] Effects of benzalkonium chloride- and polyquad-preserved combination glaucoma medications on cultured human ocular surface cells [J].

Ammar, David A. ;

Noecker, Robert J. ;

Kahook, Malik Y. .

ADVANCES IN THERAPY, 2011, 28 (06) :501-510

[2] Effects of topical antiglaucoma medications on the ocular surface [J].

Asbell, PA ;

Potapova, N .

OCULAR SURFACE, 2005, 3 (01) :27-40

[3] Systane (R) lubricant eye drops in the management of ocular dryness [J].

Benelli, Umberto .

CLINICAL OPHTHALMOLOGY, 2011, 5 :783-790

[4] Corneal Staining Reductions Observed after Treatment with Systane® Lubricant Eye Drops [J].

Christensen, Mike T. .

ADVANCES IN THERAPY, 2008, 25 (11) :1191-1199

[5] Clinical evaluation of an HP-guar gellable lubricant eye drop for the relief of dryness of the eye [J].

Christensen, MT ;

Cohen, S ;

Rinehart, J ;

Akers, F ;

Pemberton, B ;

Bloomenstein, M ;

Lesher, M ;

Kaplan, D ;

Meadows, D ;

Meuse, P ;

Hearn, C ;

Stein, JM .

CURRENT EYE RESEARCH, 2004, 28 (01) :55-62

[6] An open-label evaluation of HP-Guar gellable lubricant eye drops for the improvement of dry eye signs and symptoms in a moderate dry eye adult population [J].

Hartstein, I ;

Khwarg, S ;

Przydryga, J .

CURRENT MEDICAL RESEARCH AND OPINION, 2005, 21 (02) :255-260

[7]

ICHIJIMA H, 1992, CORNEA, V11, P221

[8]

INOUE M, 1993, INVEST OPHTH VIS SCI, V34, P2313

[9] Prospective, Randomized, Controlled Comparison of SYSTANE UD Eye Drops Versus VISINE INTENSIV 1% EDO Eye Drops for the Treatment of Moderate Dry Eye [J].

Jacobi, Christina ;

Kruse, Friedrich E. ;

Cursiefen, Claus .

JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS, 2012, 28 (06) :598-603

[10] Ocular preservatives: associated risks and newer options [J].

Kaur, Indu Pal ;

Lal, Shruti ;

Rana, Cheena ;

Kakkar, Shilpa ;

Singh, Harinder .

CUTANEOUS AND OCULAR TOXICOLOGY, 2009, 28 (03) :93-103

← 1 2 3 →