Biomedical applications of glycosylphosphatidylinositol-anchored proteins

被引：26
作者：
Heider, Susanne [1 ]
Dangerfield, John A. [2 ]
Metzner, Christoph [1 ]
机构：
[1] Univ Vet Med, Inst Virol, A-1210 Vienna, Austria
[2] Anovasia Pte Ltd, Singapore 138623, Singapore
来源：
JOURNAL OF LIPID RESEARCH | 2016年 / 57卷 / 10期
基金：
奥地利科学基金会;
关键词：
cancer; human immunodeficiency virus; immunology; lipid rafts; membranes; gene therapy; molecular painting; tumor therapy; viral envelope; VIRUS-LIKE PARTICLES; PAROXYSMAL-NOCTURNAL HEMOGLOBINURIA; ANTIVIRAL IMMUNE-RESPONSES; DECAY-ACCELERATING FACTOR; CELL-SURFACE; ENVELOPED VIRUSES; VIRAL VECTORS; IN-VITRO; COMPLEMENT LYSIS; PLASMA-MEMBRANE;
D O I：
10.1194/jlr.R070201
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Glycosylphosphatidylinositol (GPI)-anchored proteins (GPI-APs) use a unique posttranslational modification to link proteins to lipid bilayer membranes. The anchoring structure consists of both a lipid and carbohydrate portion and is highly conserved in eukaryotic organisms regarding its basic characteristics, yet highly variable in its molecular details. The strong membrane targeting property has made the anchors an interesting tool for biotechnological modification of lipid membrane-covered entities from cells through extracellular vesicles to enveloped virus particles. In this review, we will take a closer look at the mechanisms and fields of application for GPI-APs in lipid bilayer membrane engineering and discuss their advantages and disadvantages for biomedicine.
引用
收藏
页码：1778 / 1788
页数：11
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