Anthracene and 1,8-napthalimide aminothiazole hybrids: Synthesis, Antimicrobial activity and Molecular Docking Studies

被引：1
作者：
Palabindela, Rambabu [1 ]
Myadaravenia, Prabhakar [1 ]
Banothu, Devendar [1 ]
Korra, Rajashekar [1 ]
Mekala, Himabindu [1 ]
Kasula, Mamatha [1 ]
机构：
[1] Kakatiya Univ, Dept Chem, Warangal 506009, Telangana, India
来源：
ORIENTAL JOURNAL OF CHEMISTRY | 2022年 / 38卷 / 01期
关键词：
Anthracene; 1,8-Napthalimide; Aminothiazoles; Antimicrobial activity; Docking studies; ANTIBACTERIAL; DERIVATIVES; DESIGN; POTENT;
D O I：
10.13005/ojc/380117
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
With our efforts to develop potent antimicrobial agents, a series of anthracene and 1,8-napthalimide aminothiazole analogues were synthesized and characterized by using fundamental spectral analysis. All of the synthesized hybrids were screened for their anti-microbial activities against the bacterial strains E. coli, B. subtillis and S. aureus, and the fungal strains A. niger and C. albicans. Among the compounds investigated, compounds 4c, 4d, and 6c exhibited the most potent antimicrobial activity. Fluconazole and Norfloxacin were used as standard drugs for antifungal and antibacterial activity. The molecular docking investigation revealed that the compounds 4c, 4d and 6c displayed the lowest binding energy values within the promoter regions of the PDB ID (1 JIJ, 4WMZ). The in vitro antimicrobial activity results are well corroborated with the molecular docking results.
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收藏
页码：137 / 143
页数：7
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