Laser-Induced Cell Detachment and Patterning with Photodegradable Polymer Substrates

被引：47
作者：
Pasparakis, George [1 ]
Manouras, Theodore [2 ]
Selimis, Alexandros [1 ]
Vamvakaki, Maria [1 ,3 ]
Argitis, Panagiotis [2 ]
机构：
[1] FORTH, IESL, Iraklion 71110, Crete, Greece
[2] NCSR Demokritos, Inst Microelect, Athens 15310, Greece
[3] Univ Crete, Dept Mat Sci & Technol, Iraklion 71003, Crete, Greece
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 18期
关键词：
cell patterning; laser photolysis; photodegradable polymers; polyacetals; tissue engineering; PHOTOLABILE PROTECTING GROUP; ABLATION; LIGHT; COPOLYMER; TISSUE;
D O I：
10.1002/anie.201007310
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A glimpse of light is all it takes: Polymers that undergo main-chain scission at remarkably low photolysis energies were developed as efficient photodegradable substrates for safe laser-mediated cell detachment and patterning. The polymers, which contain acetal or ketal units in their backbone along with suitable absorbing groups, underwent fast degradation to release live cells upon irradiation with an excimer laser (see picture). Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：4142 / 4145
页数：4
相关论文
共 38 条
[1]  
Babin J., 2009, ANGEW CHEM, V121, P3379
[2]   A New Two-Photon-Sensitive Block Copolymer Nanocarrier [J].
Babin, Jerome ;
Pelletier, Maxime ;
Lepage, Martin ;
Allard, Jean-Francois ;
Morris, Denis ;
Zhao, Yue .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, 48 (18) :3329-3332
[3]   Patterning protein concentration using laser-assisted adsorption by photobleaching, LAPAP [J].
Belisle, Jonathan M. ;
Correia, James P. ;
Wiseman, Paul W. ;
Kennedy, Timothy E. ;
Costantino, Santiago .
LAB ON A CHIP, 2008, 8 (12) :2164-2167
[4]   Dependence of ultraviolet nanosecond laser polymer ablation on polymer molecular weight: Poly(methyl methacrylate) at 248 nm [J].
Bounos, Giannis ;
Selimis, Alexandros ;
Georgiou, Savas ;
Rebollar, Esther ;
Castillejo, Marta ;
Bityurin, Nikita .
JOURNAL OF APPLIED PHYSICS, 2006, 100 (11)
[5]   Protein micropatterns using a pH-responsive polymer and light [J].
Christman, KL ;
Maynard, HD .
LANGMUIR, 2005, 21 (18) :8389-8393
[6]   Photo-responsive systems and biomaterials: photochromic polymers, light-triggered self-assembly, surface modification, fluorescence modulation and beyond [J].
Ercole, Francesca ;
Davis, Thomas P. ;
Evans, Richard A. .
POLYMER CHEMISTRY, 2010, 1 (01) :37-54
[7]   Control of cell detachment in a microfluidic device using a thermo-responsive copolymer on a gold substrate [J].
Ernst, Oliver ;
Lieske, Antje ;
Jaeger, Magnus ;
Lankenau, Andreas ;
Duschl, Claus .
LAB ON A CHIP, 2007, 7 (10) :1322-1329
[8]   Surface engineering approaches to micropattern surfaces for cell-based assays [J].
Falconnet, D ;
Csucs, G ;
Grandin, HM ;
Textor, M .
BIOMATERIALS, 2006, 27 (16) :3044-3063
[9]   Multicomponent protein patterning of material surfaces [J].
Ganesan, Ramakrishnan ;
Kratz, Karl ;
Lendlein, Andreas .
JOURNAL OF MATERIALS CHEMISTRY, 2010, 20 (35) :7322-7331
[10]  
GREEN H, 1987, CANCER RES, V47, P410
1234