Imaging Immune and Metabolic Cells of Visceral Adipose Tissues with Multimodal Nonlinear Optical Microscopy
被引:15
作者:
Urasaki, Yasuyo
论文数: 0引用数: 0
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机构:
Desert Res Inst, Human Hlth & Environm Program, Las Vegas, NV USA
Nevada Canc Inst, Dept Drug Dev, Las Vegas, NV USADesert Res Inst, Human Hlth & Environm Program, Las Vegas, NV USA
Urasaki, Yasuyo
[1
,2
]
Johlfs, Mary G.
论文数: 0引用数: 0
h-index: 0
机构:
Roseman Univ Hlth Sci, Ctr Diabet & Obes Prevent Treatment Res & Educ, Henderson, NV USA
Roseman Univ Hlth Sci, Coll Pharm, Henderson, NV USADesert Res Inst, Human Hlth & Environm Program, Las Vegas, NV USA
Johlfs, Mary G.
[3
,4
]
Fiscus, Ronald R.
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h-index: 0
机构:
Roseman Univ Hlth Sci, Ctr Diabet & Obes Prevent Treatment Res & Educ, Henderson, NV USA
Roseman Univ Hlth Sci, Coll Pharm, Henderson, NV USADesert Res Inst, Human Hlth & Environm Program, Las Vegas, NV USA
Fiscus, Ronald R.
[3
,4
]
Le, Thuc T.
论文数: 0引用数: 0
h-index: 0
机构:
Desert Res Inst, Human Hlth & Environm Program, Las Vegas, NV USA
Nevada Canc Inst, Dept Drug Dev, Las Vegas, NV USADesert Res Inst, Human Hlth & Environm Program, Las Vegas, NV USA
Le, Thuc T.
[1
,2
]
机构:
[1] Desert Res Inst, Human Hlth & Environm Program, Las Vegas, NV USA
[2] Nevada Canc Inst, Dept Drug Dev, Las Vegas, NV USA
[3] Roseman Univ Hlth Sci, Ctr Diabet & Obes Prevent Treatment Res & Educ, Henderson, NV USA
[4] Roseman Univ Hlth Sci, Coll Pharm, Henderson, NV USA
Visceral adipose tissue (VAT) inflammation is recognized as a mechanism by which obesity is associated with metabolic diseases. The communication between adipose tissue macrophages (ATMs) and adipocytes is important to understanding the interaction between immunity and energy metabolism and its roles in obesity-induced diseases. Yet visualizing adipocytes and macrophages in complex tissues is challenging to standard imaging methods. Here, we describe the use of a multimodal nonlinear optical (NLO) microscope to characterize the composition of VATs of lean and obese mice including adipocytes, macrophages, and collagen fibrils in a label-free manner. We show that lipid metabolism processes such as lipid droplet formation, lipid droplet microvesiculation, and free fatty acids trafficking can be dynamically monitored in macrophages and adipocytes. With its versatility, NLO microscopy should be a powerful imaging tool to complement molecular characterization of the immunity-metabolism interface.
机构:
Univ Calif Los Angeles, Howard Hughes Med Inst, Dept Pathol & Lab Med, David Geffen Sch Med, Los Angeles, CA 90049 USAUniv Calif Los Angeles, Howard Hughes Med Inst, Dept Pathol & Lab Med, David Geffen Sch Med, Los Angeles, CA 90049 USA
Bensinger, Steven J.
Tontonoz, Peter
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机构:
Univ Calif Los Angeles, Howard Hughes Med Inst, Dept Pathol & Lab Med, David Geffen Sch Med, Los Angeles, CA 90049 USAUniv Calif Los Angeles, Howard Hughes Med Inst, Dept Pathol & Lab Med, David Geffen Sch Med, Los Angeles, CA 90049 USA
机构:
Univ Calif Los Angeles, Howard Hughes Med Inst, Dept Pathol & Lab Med, David Geffen Sch Med, Los Angeles, CA 90049 USAUniv Calif Los Angeles, Howard Hughes Med Inst, Dept Pathol & Lab Med, David Geffen Sch Med, Los Angeles, CA 90049 USA
Bensinger, Steven J.
Tontonoz, Peter
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Howard Hughes Med Inst, Dept Pathol & Lab Med, David Geffen Sch Med, Los Angeles, CA 90049 USAUniv Calif Los Angeles, Howard Hughes Med Inst, Dept Pathol & Lab Med, David Geffen Sch Med, Los Angeles, CA 90049 USA