Effect of Perinatal Bisphenol A Exposure on Serum Lipids and Lipid Enzymes in Offspring Rats of Different Sex

被引：22

作者：

Gao Liang ^{[1
]}

Wang Han Ning ^{[2
]}

Zhang Ling ^{[1
]}

Peng Fang Yuan ^{[1
]}

Jia Yue ^{[1
]}

Wei Wei ^{[1
]}

Jia Li Hong ^{[1
]}

机构：

[1] China Med Univ, Sch Publ Hlth, Dept Child & Adolescent Hlth, Shenyang 110122, Liaoning, Peoples R China

[2] China Med Univ, Affiliated Hosp 1, Dept Sports Med & Joint Surg, Shenyang 110001, Liaoning, Peoples R China

来源：

BIOMEDICAL AND ENVIRONMENTAL SCIENCES | 2016年 / 29卷 / 09期

关键词：

BODY-MASS INDEX; CHILDHOOD; OBESITY; COHORT;

D O I：

10.3967/bes2016.092

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Rats were exposed to 1 or 10 mu g/mL bisphenol A (BPA) in water during pregnancy and lactation. Offspring rats were given normal water and a standard diet from weaning to postnatal day (PND) 50. Perinatal exposure to BPA resulted in significantly increased body weight, visceral adipose tissue, abnormal serum lipids, and lower adiponectin (ADP) levels in both female and male offspring rats. Liver adipose triglyceride lipase (Atgl) mRNA levels and ADP protein in visceral adipose tissue were significantly decreased in BPA-exposed offspring rats. In both female or male offspring rats, obesity and dyslipidemia induced by perinatal exposure to BPA were associated with down regulation of Atgl mRNA in liver and ADP protein in visceral adipose tissue.

引用

页码：686 / +

页数：5

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