Expression of carbonic anhydrase IX in genitourinary and adrenal tumours

被引:19
作者
Donato, Daniel P. [1 ]
Johnson, Matthew T. [2 ]
Yang, Ximing J. [3 ]
Zynger, Debra L. [1 ]
机构
[1] Ohio State Univ, Med Ctr, Dept Pathol, Columbus, OH 43210 USA
[2] Ohio State Univ, Med Ctr, Dept Urol, Columbus, OH 43210 USA
[3] Northwestern Univ, Dept Pathol, Feinberg Sch Med, Chicago, IL 60611 USA
关键词
adrenal; carbonic anhydrase IX; immunohistochemistry; testis; RENAL-CELL CARCINOMA; ENDOTHELIAL GROWTH-FACTOR; INVASIVE BLADDER-CANCER; CA-IX; INDEPENDENT PREDICTOR; PROSTATE-CANCER; POOR-PROGNOSIS; HYPOXIA; SURVIVAL; PROTEIN;
D O I
10.1111/j.1365-2559.2011.04074.x
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Aims: High expression of carbonic anhydrase IX (CAIX) is reported for clear cell renal cell carcinoma (RCC), with a paucity of data for non-renal genitourinary or adrenal tumours. This study investigated the immunohistochemical expression of CAIX throughout the genitourinary tract and adrenal gland. Methods and results: High expression in the renal cortex was restricted to clear cell, papillary and clear cell papillary RCC and carcinoid. Core biopsies of clear cell RCC were consistently positive. Positivity within the urothelial tract was seen in urothelial carcinoma including squamous, small-cell, sarcomatoid and adenomatous differentiation and clear cell adenocarcinoma. Signet ring and plasmacytoid variants of urothelial carcinoma were negative. Phaeochromocytoma, adrenal cortical adenoma, seminoma, yolk sac tumour, choriocarcinoma, Leydig cell tumour and prostatic adenocarcinoma were predominately negative, with variable reactivity in adrenal cortical carcinoma, embryonal carcinoma, teratoma and Sertoli cell tumour. Conclusions: Carbonic anhydrase IX is a sensitive marker for clear cell RCC in core biopsies. However, other genitourinary or adrenal tumours that can have a clear cell appearance including urothelial, squamous cell, clear cell adeno and adrenal cortical carcinoma and Sertoli cell tumour express CAIX. Knowledge of expression overlap between these entities may prevent incorrect interpretation of immunohistochemical results, particularly if limited tissue is available.
引用
收藏
页码:1229 / 1239
页数:11
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