Agelamadin F and tauroacidin E, bromopyrrole alkaloids from an Okinawan marine sponge Agelas sp.

被引：20

作者：

Kusama, Taishi ^{[1
,2
]}

Tanaka, Naonobu ^{[2
]}

Kashiwada, Yoshiki ^{[2
]}

Kobayashi, Jun'ichi ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan

[2] Univ Tokushima, Grad Sch Pharmaceut Sci, Tokushima 7708505, Japan

来源：

TETRAHEDRON LETTERS | 2015年 / 56卷 / 30期

关键词：

Marine sponge; Agelas sp; Bromopyrrole alkaloid; Agelamadin F; Tauroacidin E; OROIDIN;

D O I：

10.1016/j.tetlet.2015.05.114

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new structurally unique bromopyrrole alkaloid, agelamadin F (1), comprising oroidin and 3-hydroxypyridinium was isolated from an Okinawan marine sponge Agelas sp. together with tauroacidin E (2), a new bromopyrrole alkaloid possessing a taurine moiety. Six known bromopyrrole alkaloids, oroidin, tauroacidin A, sceptrin, ageliferin, nagelamide E, and agelongine were also isolated and identified. The structures of 1 and 2 were elucidated on the basis of spectroscopic evidences, while chiral HPLC analysis suggested tauroacidin E (2) to be a racemate. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：4502 / 4504

页数：3

共 17 条

[11] Agelamadins C-E, Bromopyrrole Alkaloids Comprising Oroidin and 3-Hydroxykynurenine from a Marine Sponge Agelas sp. [J].