Agelamadin F and tauroacidin E, bromopyrrole alkaloids from an Okinawan marine sponge Agelas sp.

被引：20
作者：
Kusama, Taishi [1 ,2 ]
Tanaka, Naonobu [2 ]
Kashiwada, Yoshiki [2 ]
Kobayashi, Jun'ichi [1 ]
机构：
[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan
[2] Univ Tokushima, Grad Sch Pharmaceut Sci, Tokushima 7708505, Japan
来源：
TETRAHEDRON LETTERS | 2015年 / 56卷 / 30期
关键词：
Marine sponge; Agelas sp; Bromopyrrole alkaloid; Agelamadin F; Tauroacidin E; OROIDIN;
D O I：
10.1016/j.tetlet.2015.05.114
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new structurally unique bromopyrrole alkaloid, agelamadin F (1), comprising oroidin and 3-hydroxypyridinium was isolated from an Okinawan marine sponge Agelas sp. together with tauroacidin E (2), a new bromopyrrole alkaloid possessing a taurine moiety. Six known bromopyrrole alkaloids, oroidin, tauroacidin A, sceptrin, ageliferin, nagelamide E, and agelongine were also isolated and identified. The structures of 1 and 2 were elucidated on the basis of spectroscopic evidences, while chiral HPLC analysis suggested tauroacidin E (2) to be a racemate. (C) 2015 Elsevier Ltd. All rights reserved.
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收藏
页码：4502 / 4504
页数：3
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