Detection of enzymatic activity by PARACEST MRI:: A general approach to target a large variety of enzymes

被引：119

作者：

Chauvin, Thomas ^{[2
]}

Durand, Philippe ^{[1
]}

Bernier, Michele ^{[1
]}

Meudal, Herve ^{[2
]}

Doan, Bich-Thuy ^{[2
]}

Noury, Fanny ^{[2
]}

Badet, Bernard ^{[1
]}

Beloeil, Jean-Claude ^{[2
]}

Toth, Eva ^{[2
]}

机构：

[1] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

[2] CNRS, Ctr Biophys Mol, F-45071 Orleans 2, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 23期

关键词：

imaging agents; lanthanides; PARACEST; proton exchange; saturation transfer;

D O I：

10.1002/anie.200800809

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Perfect timing: A "smart" pro-PARACEST agent has been designed to detect β-galactosidase activity. Upon enzymatic attack, the self-immolative benzyloxycarbamate linker bearing the enzyme-specific substrate is cleaved and yields [Yb(dota-NH2)] -, which is endowed with a PARACEST effect. This pro-PARACEST agent is the first representative of a family of molecular imaging probes for the specific detection of a large variety of enzymatic activities using PARACEST. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4370 / 4372

页数：3

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