Cholinergic axon length reduced by 300 meters in the brain of an Alzheimer mouse model

被引：19

作者：

Nikolajsen, Gitte Nykjaer ^{[1
]}

Jensen, Morten Skovgaard ^{[1
]}

West, Mark J. ^{[1
]}

机构：

[1] Aarhus Univ, Inst Biomed, DK-8000 Aarhus C, Denmark

来源：

NEUROBIOLOGY OF AGING | 2011年 / 32卷 / 11期

关键词：

VAChT; Stereology; Space balls; Axons; Fractionator; AMYLOID DEPOSITION; SELECTIVE LOSS; DISEASE; PRESENILIN-1; NEURONS;

D O I：

10.1016/j.neurobiolaging.2011.05.006

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Modern stereological techniques have been used to show that the total length of the cholinergic fibers in the cerebral cortex of the APPswe/PS1deltaE9 mouse is reduced by almost 300 meters at 18 months of age and has a nonlinear relationship to the amount of transgenetically-induced amyloidosis. These data provide rigorous quantitative morphological evidence that Alzheimer's-like amyloidosis affects the axons of the cholinergic enervation of the cerebral cortex. (C) 2011 Published by Elsevier Inc.

引用

页码：1927 / 1931

页数：5

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