Left cardiac sympathetic denervation for catecholaminergic polymorphic ventricular tachycardia

被引：293

作者：

Wilde, Arthur A. M. ^{[1
]}

Bhuiyan, Zahurul A. ^{[1
]}

Crotti, Lia ^{[2
,3
]}

Facchini, Mario ^{[4
]}

De Ferrari, Gaetano M. ^{[3
]}

Paul, Thomas ^{[5
]}

Ferrandi, Chiara ^{[3
]}

Koolbergen, Dave R. ^{[1
]}

Odero, Attilio ^{[2
,3
]}

Schwartz, Peter J. ^{[2
,3
,4
,6
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Dept Cardiol, NL-1105 AZ Amsterdam, Netherlands

[2] Univ Pavia, I-27100 Pavia, Italy

[3] IRCCS, Fdn Policlin S Matteo, Pavia, Italy

[4] IRCCS, Ist Auxol, Milan, Italy

[5] Univ Gottingen, Univ Childrens Hosp, Gottingen, Germany

[6] Univ Cape Town, ZA-7925 Cape Town, South Africa

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2008年 / 358卷 / 19期

关键词：

D O I：

10.1056/NEJMoa0708006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Catecholaminergic polymorphic ventricular tachycardia is a potentially lethal disease characterized by adrenergically mediated ventricular arrhythmias manifested especially in children and teenagers. Beta-blockers are the cornerstone of therapy, but some patients do not have a complete response to this therapy and receive an implantable cardioverter-defibrillator (ICD). Given the nature of catecholaminergic polymorphic ventricular tachycardia, ICD shocks may trigger new arrhythmias, leading to the administration of multiple shocks. We describe the long-term efficacy of surgical left cardiac sympathetic denervation in three young adults with catecholaminergic polymorphic ventricular tachycardia, all of whom had symptoms before the procedure and were symptom-free afterward.

引用

页码：2024 / 2029

页数：6

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