Multifunctional magnetic gold nanocomposites: Human epithelial cancer detection via magnetic resonance imaging and localized synchronous therapy

被引：114

作者：

Lee, Jaewon ^{[1
]}

Yang, Jaemoon ^{[1
]}

Ko, Hyunju

Oh, Seung Jae ^{[3
]}

Kang, Jinyoung ^{[1
]}

Son, Joo-Hriuk ^{[3
]}

Lee, Kwangyeol ^{[4
]}

Lee, Sang-Wha ^{[5
]}

Yoon, Ho-Geun ^{[6
]}

Suh, Jin-Suck ^{[2
]}

Huh, Yong-Min ^{[2
]}

Haam, SeungJoo ^{[1
]}

机构：

[1] Yonsei Univ, Dept Chem Engn, Seoul 120749, South Korea

[2] Yonsei Univ, Dept Radiol, Seoul 120749, South Korea

[3] Univ Seoul, Dept Phys, Seoul 130743, South Korea

[4] Korea Univ, Dept Chem, Seoul 136701, South Korea

[5] Kyungwon Univ, Dept Chem & Bio Engn, Gyeonggi Do 461701, South Korea

[6] Yonsei Univ, Dept Biochem & Mol Biol, Seoul 120749, South Korea

来源：

ADVANCED FUNCTIONAL MATERIALS | 2008年 / 18卷 / 02期

关键词：

D O I：

10.1002/adfm.200700482

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Novel multifunctional magnetic gold nanocomposites (MGNCs) were synthesized for synchronous cancer therapy and diagnosis via magnetic resonance imaging (MRI). The MGNCs consist of magnetic kernels (aggregates of ultra-sensitive MnFe2O4 magnetic nanocrystals wrapped in polymer) as effective MR contrast agents and silica-gold nanocomposites as hyperthermal therapeutic agents. A therapeutic antibody, Erbitux (ERB), was conjugated for specific tumor cell targeting both to localize the near-IR laser beam and to image their events through MRI. ERB-conjugated MGNCs selectively recognize the target cancer cell lines. Fluorescence images and MRI analysis show that the MGNCs are effectively taken up by the cells. ERB-conjugated MGNCs have an excellent synchronous therapeutic efficacy as a result of the therapeutic antibody and near-IR laser-induced surface plasmon resonance. Consequently, MGNCs clearly demonstrate selective imaging and treatment of human epithelia] cancer simultaneously.

引用

页码：258 / 264

页数：7

共 39 条

[1] Controlled clustering of superparamagnetic nanoparticles using block copolymers: Design of new contrast agents for magnetic resonance imaging [J].

Berret, JF ;

Schonbeck, N ;

Gazeau, F ;

El Kharrat, D ;

Sandre, O ;

Vacher, A ;

Airiau, M .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (05) :1755-1761

[2] Gold nanocages: Engineering their structure for biomedical applications [J].

Chen, JY ;

Wiley, B ;

Li, ZY ;

Campbell, D ;

Saeki, F ;

Cang, H ;

Au, L ;

Lee, J ;

Li, XD ;

Xia, YN .

ADVANCED MATERIALS, 2005, 17 (18) :2255-2261

[3] Investigation of formation of silica-coated magnetite nanoparticles via sol-gel approach [J].

Deng, YH ;

Wang, CC ;

Hu, JH ;

Yang, WL ;

Fu, SK .

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2005, 262 (1-3) :87-93

[4] Semiconductor quantum rods as single molecule fluorescent biological labels [J].

Fu, Aihua ;

Gu, Weiwei ;

Boussert, Benjamin ;

Koski, Kristie ;

Gerion, Daniele ;

Manna, Liberato ;

Le Gros, Mark ;

Larabell, Carolyn A. ;

Alivisatos, A. Paul .

NANO LETTERS, 2007, 7 (01) :179-182

[5] Metallodielectric colloidal core-shell particles for photonic applications [J].

Graf, C ;

van Blaaderen, A .

LANGMUIR, 2002, 18 (02) :524-534

[6] Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance [J].

Hirsch, LR ;

Stafford, RJ ;

Bankson, JA ;

Sershen, SR ;

Rivera, B ;

Price, RE ;

Hazle, JD ;

Halas, NJ ;

West, JL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (23) :13549-13554

[7] Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods [J].

Huang, XH ;

El-Sayed, IH ;

Qian, W ;

El-Sayed, MA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (06) :2115-2120

[8] In vivo magnetic resonance detection of cancer by using multifunctional magnetic nanocrystals [J].

Huh, YM ;

Jun, YW ;

Song, HT ;

Kim, S ;

Choi, JS ;

Lee, JH ;

Yoon, S ;

Kim, KS ;

Shin, JS ;

Suh, JS ;

Cheon, J .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (35) :12387-12391

[9] Tailoring air defects in self-assembled photonic bandgap crystals [J].

Jun, Y ;

Leatherdale, CA ;

Norris, DJ .

ADVANCED MATERIALS, 2005, 17 (15) :1908-+

[10] Nanoscale size effect of magnetic nanocrystals and their utilization for cancer diagnosis via magnetic resonance imaging [J].