REGENERATIVE BIOLOGY Neuregulin 1 makes heart muscle

被引：23

作者：

Yutzey, Katherine E. ^{[1
]}

机构：

[1] Cincinnati Childrens Med Ctr, Div Mol Cardiovasc Biol, Cincinnati, OH 45229 USA

来源：

NATURE | 2015年 / 520卷 / 7548期

关键词：

RENEWAL;

D O I：

10.1038/520445a

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Three studies reveal that augmentation of a signalling pathway involving the growth factor neuregulin 1 and its receptor protein ERBB2 can promote the generation of muscle cells in zebrafish, mice and infant heart tissue.

引用

页码：445 / 446

页数：2

共 10 条

[1] Evidence for Cardiomyocyte Renewal in Humans [J].

Bergmann, Olaf ;

Bhardwaj, Ratan D. ;

Bernard, Samuel ;

Zdunek, Sofia ;

Barnabe-Heider, Fanie ;

Walsh, Stuart ;

Zupicich, Joel ;

Alkass, Kanar ;

Buchholz, Bruce A. ;

Druid, Henrik ;

Jovinge, Stefan ;

Frisen, Jonas .

SCIENCE, 2009, 324 (5923) :98-102

[2] Neuregulin1/ErbB4 Signaling Induces Cardiomyocyte Proliferation and Repair of Heart Injury [J].

Bersell, Kevin ;

Arab, Shima ;

Haring, Bernhard ;

Kuehn, Bernhard .

CELL, 2009, 138 (02) :257-270

[3] BASIC IMPLICATIONS OF CLINICAL OBSERVATIONS ERBB2 Inhibition and Heart Failure [J].

Cote, Gregory M. ;

Sawyer, Douglas B. ;

Chabner, Bruce A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 367 (22) :2150-2153

[4]

D'Uva G., 2015, NATURE CELL BIOL

[5] Nrg1 is an injury-induced cardiomyocyte mitogen for the endogenous heart regeneration program in zebrafish [J].

Gemberling, Matthew ;

Karra, Ravi ;

Dickson, Amy L. ;

Poss, Kenneth D. .

ELIFE, 2015, 4

[6] Neuregulin stimulation of cardiomyocyte regeneration in mice and human myocardium reveals a therapeutic window [J].

Polizzotti, Brian D. ;

Ganapathy, Balakrishnan ;

Walsh, Stuart ;

Choudhury, Sangita ;

Ammanamanchi, Niyatie ;

Bennett, David G. ;

dos Remedios, Cristobal G. ;

Haubner, Bernhard J. ;

Penninger, Josef M. ;

Kuehn, Bernhard .

SCIENCE TRANSLATIONAL MEDICINE, 2015, 7 (281)

[7] Heart regeneration in zebrafish [J].

Poss, KD ;

Wilson, LG ;

Keating, MT .

SCIENCE, 2002, 298 (5601) :2188-2190

[8] Recombinant Neuregulin 1 Does Not Activate Cardiomyocyte DNA Synthesis in Normal or Infarcted Adult Mice [J].

Reuter, Sean ;

Soonpaa, Mark H. ;

Firulli, Anthony B. ;

Chang, Audrey N. ;

Field, Loren J. .

PLOS ONE, 2014, 9 (12)

[9] Mammalian heart renewal by pre-existing cardiomyocytes [J].

Senyo, Samuel E. ;

Steinhauser, Matthew L. ;

Pizzimenti, Christie L. ;

Yang, Vicky K. ;

Cai, Lei ;

Wang, Mei ;

Wu, Ting-Di ;

Guerquin-Kern, Jean-Luc ;

Lechene, Claude P. ;

Lee, Richard T. .

NATURE, 2013, 493 (7432) :433-U186

[10] Survey of studies examining mammalian cardiomyocyte DNA synthesis [J].

Soonpaa, MH ;

Field, LJ .

CIRCULATION RESEARCH, 1998, 83 (01) :15-26

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