Preventing peptide and protein misbehavior

被引：7

作者：

Arosio, Paolo ^{[1
]}

Meisl, Georg ^{[1
]}

Andreasen, Maria ^{[1
]}

Knowles, Tuomas P. J. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2015年 / 112卷 / 17期

关键词：

AGGREGATION DISEASES; NUCLEATION MECHANISM; AMYLOID FIBRILS; KINETICS; PROTEOSTASIS; POLYMORPHISM;

D O I：

10.1073/pnas.1505170112

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：5267 / 5268

页数：2

共 21 条

[1] Zinc as chaperone-mimicking agent for retardation of amyloid β peptide fibril formation [J].

Abelein, Axel ;

Graslund, Astrid ;

Danielsson, Jens .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (17) :5407-5412

[2] Protein aggregation diseases: pathogenicity and therapeutic perspectives [J].

Aguzzi, Adriano ;

O'Connor, Tracy .

NATURE REVIEWS DRUG DISCOVERY, 2010, 9 (03) :237-248

[3]

[Anonymous], 2012, DEM PUBL HLTH PRIOR

[4] Chemical kinetics for drug discovery to combat protein aggregation diseases [J].

Arosio, Paolo ;

Vendruscolo, Michele ;

Dobson, Christopher M. ;

Knowles, Tuomas P. J. .

TRENDS IN PHARMACOLOGICAL SCIENCES, 2014, 35 (03) :127-135

[5] Adapting proteostasis for disease intervention [J].

Balch, William E. ;

Morimoto, Richard I. ;

Dillin, Andrew ;

Kelly, Jeffery W. .

SCIENCE, 2008, 319 (5865) :916-919

[6] Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation [J].

Buell, Alexander K. ;

Galvagnion, Celine ;

Gaspar, Ricardo ;

Sparr, Emma ;

Vendruscolo, Michele ;

Knowles, Tuomas P. J. ;

Linse, Sara ;

Dobson, Christopher M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (21) :7671-7676

[7] A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers [J].

Cohen, Samuel I. A. ;

Arosio, Paolo ;

Presto, Jenny ;

Kurudenkandy, Firoz Roshan ;

Biverstal, Henrik ;

Dolfe, Lisa ;

Dunning, Christopher ;

Yang, Xiaoting ;

Frohm, Birgitta ;

Vendruscolo, Michele ;

Johansson, Jan ;

Dobson, Christopher M. ;

Fisahn, Andre ;

Knowles, Tuomas P. J. ;

Linse, Sara .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2015, 22 (03) :207-213

[8] Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism [J].

Cohen, Samuel I. A. ;

Linse, Sara ;

Luheshi, Leila M. ;

Hellstrand, Erik ;

White, Duncan A. ;

Rajah, Luke ;

Otzen, Daniel E. ;

Vendruscolo, Michele ;

Dobson, Christopher M. ;

Knowles, Tuomas P. J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (24) :9758-9763

[9] Protein folding and misfolding [J].

Dobson, CM .

NATURE, 2003, 426 (6968) :884-890

[10] The Amyloid State of Proteins in Human Diseases [J].

Eisenberg, David ;

Jucker, Mathias .

CELL, 2012, 148 (06) :1188-1203

← 1 2 3 →