Electrical stimulation on adverse events caused by chemotherapy in patients with cervical cancer A protocol for a systematic review of randomized controlled trial

Background: This protocol of systematic review aims to investigate the effectiveness of electrical stimulation (ES) on adverse events (AEs) caused by chemotherapy in patients with cervical cancer (CC). Methods: This systematic review of randomized controlled trials will be identified through searchers of PUBMED, PsycINFO, Scopus, Opengrey, Cochrane Central Register of Controlled Trials, EMBASE, Cumulative Index to Nursing and Allied Health Literature, Web of Science, Allied and Complementary Medicine Database, and Chinese Biomedical Literature Database. All the sources will be searched from the inception to the date of study search ran. Additionally, websites of clinical trials registry and reference lists provided in relevant studies and reviews will also be searched. Two independent reviewers will evaluate the eligibility criteria of all potential literature, extract the data, and determine the risk of bias for each included study. RevMan 5.3 software will be used to pool the data and to conduct a meta-analysis. Results: This systematic review will assess the effectiveness of ES on AEs caused by chemotherapy in patients with CC. Conclusion: The findings of this study may summarize the latest evidence for the ES on AEs following chemotherapy for CC. PROSPERO registration number: PROSPERO CRD42019120191.