Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes

被引：319

作者：

Takahashi, Michiko ^{[1
]}

Takahashi, Yutaka ^{[1
]}

Takahashi, Kenichi ^{[2
]}

Zolotaryov, Fyodor N. ^{[2
]}

Hong, Kyoung Su ^{[2
]}

Kitazawa, Riko ^{[3
]}

Iida, Keiji ^{[1
]}

Okimura, Yasuhiko ^{[4
]}

Kaji, Hidesuke ^{[5
]}

Kitazawa, Sohei ^{[3
]}

Kasuga, Masato ^{[1
]}

Chihara, Kazuo ^{[1
]}

机构：

[1] Kobe Univ, Grad Sch Med, Dept Internal Med, Div Endocrinol Diabet & Metab,Chuo Ku, Kobe, Hyogo 6500017, Japan

[2] JCR Pharmaceut Co Ltd, Res Affairs Ctr, Div Res, Nishi Ku, Kobe, Hyogo 6512241, Japan

[3] Kobe Univ, Grad Sch Med, Dept Biomed Informat, Div Mol Pathol, Kobe, Hyogo 6500017, Japan

[4] Kobe Univ, Sch Med, Dept Basic Allied Med, Suma Ku, Kobe, Hyogo 6540142, Japan

[5] Univ Hyogo, Div Physiol Metab, Akashi, Hyogo 6738588, Japan

来源：

FEBS LETTERS | 2008年 / 582卷 / 05期

关键词：

adipokine; chemerin; insulin signaling; adipocyte differentiation; 3T3-L1; adipocyte; insulin sensitivity;

D O I：

10.1016/j.febslet.2008.01.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To explore a novel adipokine, we screened adipocyte differentiation-related gene and found that TIG2/chemerin was strongly induced during the adipocyte differentiation. Chemerin was secreted by the mature 3T3-L1 adipocytes and expressed abundantly in adipose tissue in vivo as recently described. Intriguingly, the expression of chemerin was differently regulated in the liver and adipose tissue in db/db mice. In addition, serum chemerin concentration was decreased in db/db mice. Chemerin and its receptor/ChemR23 were expressed in mature adipocytes, suggesting its function in autocrine/paracrine fashion. Finally, chemerin potentiated insulin-stimulated glucose uptake concomitant with enhanced insulin signaling in the 3T3-L1 adipocytes. These data establish that chemerin is a novel adipokine that regulates adipocyte function. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：573 / 578

页数：6

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