Independent Regulation of Na+ and K+ Balance by the Kidney

被引：16

作者：

Castaneda-Bueno, Maria

Pablo Arroyo, Juan

Gamba, Gerardo ^{[1
]}

机构：

[1] Univ Nacl Autonoma Mexico, Mol Physiol Unit, Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Inst Nacl Cardiol Ignacio Chavez, Mexico City 14000, DF, Mexico

来源：

MEDICAL PRINCIPLES AND PRACTICE | 2012年 / 21卷 / 02期

关键词：

Angiotensin II; Aldosterone; Sodium balance; Potassium balance; Na+/Cl- cotransporter; Renal outer medullary K+ channel; Apical Na+ channel; WNK kinases; EPITHELIAL SODIUM-CHANNEL; CORTICAL COLLECTING DUCT; RENAL POTASSIUM EXCRETION; CELL-SURFACE EXPRESSION; ANGIOTENSIN-II; CL-COTRANSPORTER; WNK KINASES; BLOOD-PRESSURE; DISTAL TUBULE; CONNECTING TUBULE;

D O I：

10.1159/000332580

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The understanding of the independent regulation of sodium and potassium by the kidney has remained elusive. Recent evidence now points to dissimilar regulatory mechanisms in ion handling, dependent on the presence of either aldosterone alone or angiotensin II with aldosterone among other factors. This review summarizes past and present information in an attempt to reconcile the current concepts of differential regulation of sodium and potassium balance through the with-no-lysine (K) kinase (WNK) system and the previous knowledge regarding ion transport mechanisms in the distal nephron. Copyright (C) 2011 S. Karger AG, Basel

引用

页码：101 / 114

页数：14

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