Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock

被引:404
作者
Rando, Thomas A. [1 ,2 ,5 ,6 ]
Chang, Howard Y. [1 ,3 ,4 ]
机构
[1] Stanford Univ, Sch Med, Glenn Labs Biol Aging, Stanford, CA 94305 USA
[2] Stanford Univ, Sch Med, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA
[3] Stanford Univ, Sch Med, Howard Hughes Med Inst, Stanford, CA 94305 USA
[4] Stanford Univ, Sch Med, Program Epithelial Biol, Stanford, CA 94305 USA
[5] VA Palo Alto Hlth Care Syst, RR&D Ctr Excellence, Palo Alto, CA 94304 USA
[6] VA Palo Alto Hlth Care Syst, Neurol Serv, Palo Alto, CA 94304 USA
关键词
EXTENDS LIFE-SPAN; STEM-CELLS; GENE-EXPRESSION; CALORIE RESTRICTION; GENOMIC INSTABILITY; HEMATOPOIETIC STEM; DNA METHYLATION; NONCODING RNA; SOMATIC-CELLS; PLURIPOTENCY;
D O I
10.1016/j.cell.2012.01.003
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The underlying cause of aging remains one of the central mysteries of biology. Recent studies in several different systems suggest that not only may the rate of aging be modified by environmental and genetic factors, but also that the aging clock can be reversed, restoring characteristics of youthfulness to aged cells and tissues. This Review focuses on the emerging biology of rejuvenation through the lens of epigenetic reprogramming. By defining youthfulness and senescence as epigenetic states, a framework for asking new questions about the aging process emerges.
引用
收藏
页码:46 / 57
页数:12
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