Cystic fibrosis (cf) and ovarian reserve: A cross-sectional study examining serum anti-mullerian hormone (amh) in young women

被引：27

作者：

Schram, C. A. ^{[1
]}

Stephenson, A. L. ^{[2
]}

Hannam, T. G. ^{[3
]}

Tullis, E. ^{[2
]}

机构：

[1] Womens Coll Hosp, Dept Family & Community Med, Toronto, ON M5S 1B1, Canada

[2] St Michaels Hosp, Dept Respirol, Adult Cyst Fibrosis Clin, Toronto, ON M5B 1W8, Canada

[3] Hannam Fertil Ctr, Toronto, ON M4W 1B9, Canada

来源：

JOURNAL OF CYSTIC FIBROSIS | 2015年 / 14卷 / 03期

关键词：

Cystic fibrosis; Fertility; Pregnancy; Anti-mullerian hormone; CERVICAL MUCUS; INFERTILITY; FERTILITY; PREGNANCY; ISSUES; ADULTS; MEN;

D O I：

10.1016/j.jcf.2014.09.008

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Background: Reduced female fertility in CF is believed to be due to thick cervical mucous, poor nutritional status, functional hypogonadotropic hypogonadism and possibly increased inflammation. Literature suggests that reduced ovarian reserve may also play a role. Methods: 20 women with CF and 20 controls age 18-35 years were recruited. Serum anti-mullerian hormone (AMH), estradiol and follicle stimulating hormone (FSH) were assessed as well as antral follicle count (AFC) using transvaginal ultrasound. Results: Women with CF had significantly lower AMH levels than controls (17.8 +/- 4.7 vs. 33.2 +/- 21.0 pmol/L respectively; p = 0.004). There were no differences in estradiol, FSH or AFC. Conclusions: Women with CF have reduced ovarian reserve which may contribute to sub-fertility. CF care providers should consider referring women with CF to fertility specialists early to optimize chances of pregnancy. (C) 2014 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.

引用

页码：398 / 402

页数：5

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