Antitumor effect of hepatocyte growth factor on hepatoblastoma

被引：0

作者：

Tsunoda, Y ^{[1
]}

Shibusawa, M ^{[1
]}

Tsunoda, A ^{[1
]}

Gomi, A ^{[1
]}

Yatsuzuka, M ^{[1
]}

Okamatsu, T ^{[1
]}

机构：

[1] Showa Univ, Sch Med, Dept Surg, Shinagawa Ku, Tokyo 142, Japan

来源：

ANTICANCER RESEARCH | 1998年 / 18卷 / 6A期

关键词：

hepatoblastoma; xenograft; alpha-fetoprotein; hepatocyte growth factor (HGF);

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A six month-old girl presented with an abdominal mass, and high serum level of alpha-fetoprotein. She was diagnosed as having a well-differentiated hepatoblastoma By open biopsy. The biopsy specimen was transplanted on a nude mouse, and a xenograft was successfully established. Because the xenograft maintained the charactaristics of the original tumor; the effect of hepatocyte growth factor (HGF) on hepatoblastoma xenograft was investigated. Recently HGF was reported to be involved in growth, invasion, and metastasis of tumor cells. Contrary to our expectations, the treatment of hepatoblastoma xenograft with recombinant 20 ng/ml HGF produced a mar ked inhibition of cell growth and a suppression of producing alpha-fetoprotein.

引用

页码：4339 / 4342

页数：4

共 11 条

[1] CARMICHAEL J, 1987, CANCER RES, V47, P936
[2] HEPATOCYTE GROWTH-FACTOR INHIBITS CELL-PROLIFERATION IN-VIVO OF RAT HEPATOCELLULAR CARCINOMAS INDUCED BY DIETHYLNITROSAMINE
LIU, ML
MARS, WM
MICHALOPOULOS, GK
[J]. CARCINOGENESIS, 1995, 16 (04) : 841 - 843
[3] Matsumoto K, 1996, J BIOCHEM-TOKYO, V119, P591
[4] HUMAN HEPATOCYTE GROWTH-FACTOR STIMULATES THE GROWTH OF HUH-6 CLONE-5 HUMAN HEPATOBLASTOMA CELLS
MIYAZAKI, M
GOHDA, E
TSUBOI, S
TSUBOUCHI, H
DAIKUHARA, Y
NAMBA, M
YAMAMOTO, I
[J]. CELL BIOLOGY INTERNATIONAL REPORTS, 1992, 16 (02) : 145 - 154
[5] RAPID COLORIMETRIC ASSAY FOR CELLULAR GROWTH AND SURVIVAL - APPLICATION TO PROLIFERATION AND CYTO-TOXICITY ASSAYS
MOSMANN, T
[J]. JOURNAL OF IMMUNOLOGICAL METHODS, 1983, 65 (1-2) : 55 - 63
[6] MOLECULAR-CLONING AND EXPRESSION OF HUMAN HEPATOCYTE GROWTH-FACTOR
NAKAMURA, T
NISHIZAWA, T
HAGIYA, M
SEKI, T
SHIMONISHI, M
SUGIMURA, A
TASHIRO, K
SHIMIZU, S
[J]. NATURE, 1989, 342 (6248) : 440 - 443
[7] PURIFICATION AND SUBUNIT STRUCTURE OF HEPATOCYTE GROWTH-FACTOR FROM RAT PLATELETS
NAKAMURA, T
NAWA, K
ICHIHARA, A
KAISE, N
NISHINO, T
[J]. FEBS LETTERS, 1987, 224 (02) : 311 - 316
[8] PARTIAL-PURIFICATION AND CHARACTERIZATION OF HEPATOCYTE GROWTH-FACTOR FROM SERUM OF HEPATECTOMIZED RATS
NAKAMURA, T
NAWA, K
ICHIHARA, A
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 122 (03) : 1450 - 1459
[9] HEPATOCYTE GROWTH-FACTOR INHIBITS GROWTH OF HEPATOCELLULAR-CARCINOMA CELLS
SHIOTA, G
RHOADS, DB
WANG, TC
NAKAMURA, T
SCHMIDT, EV
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (01) : 373 - 377
[10] HEPATOCYTE GROWTH-FACTOR HAS POTENT ANTIPROLIFERATIVE ACTIVITY IN VARIOUS TUMOR-CELL LINES
TAJIMA, H
MATSUMOTO, K
NAKAMURA, T
[J]. FEBS LETTERS, 1991, 291 (02) : 229 - 232

← 1 2 →