Cyclotriphosphazene core-based dendrimers for biomedical applications: an update on recent advances

被引：80

作者：

Wang, Le ^{[1
]}

Yang, Yun-Xia ^{[1
]}

Shi, Xiangyang ^{[2
,3
]}

Mignani, Serge ^{[3
,4
]}

Caminade, Anne-Marie ^{[5
]}

Majoral, Jean-Pierre ^{[5
,6
]}

机构：

[1] Shanghai Univ Engn Sci, Coll Chem & Chem Engn, Shanghai 201620, Peoples R China

[2] Donghua Univ, Coll Chem Chem Engn & Biotechnol, Shanghai 201620, Peoples R China

[3] Univ Madeira, MMRG, CQM, Campus Penteada, P-9020105 Funchal, Portugal

[4] Univ Paris 05, PRES Sorbonne Paris Cite, CNRS UMR 860, Lab Chim & Biochim Pharmacol & Toxicol, 45 Rue St Peres, F-75006 Paris, France

[5] CNRS, LCC, 205 Route Narbonne, F-31077 Toulouse, France

[6] Univ Toulouse, UPS, INPT, F-31077 Toulouse 4, France

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2018年 / 6卷 / 06期

基金：

中国国家自然科学基金;

关键词：

PHOSPHORUS DENDRIMERS; BIOLOGICAL EVALUATION; FLUORESCENT; NANOPARTICLES; PROTEIN; COORDINATION; RESISTANCE; PERFORMANCE; COMPLEXES; CHEMISTRY;

D O I：

10.1039/c7tb03081a

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

This review is focused on the recent use of cyclotriphosphazene- based dendrimers in biomedicine. Since its synthesis for the first time in 1834, cyclotriphosphazene has been an important compound of phosphorus chemistry as a scaffold, and a large number of cyclotriphosphazene derivatives have been synthesized and applied in various fields such as biology, catalysis, fluorescence, nanomaterials, etc. Today, one of the most important uses concerns its biomedical applications. In this review, the recent developments (since 2012) of cyclotriphosphazene for major pharmaceutical applications are highlighted and analyzed.

引用

页码：884 / 895

页数：12

共 65 条

[1]

Ahamad T., 2012, MIDDLE E J CANC, V15, P476

[2] Bioerodible polyphosphazenes and their medical potential [J].

Allcock, Harry R. ;

Morozowich, Nicole L. .

POLYMER CHEMISTRY, 2012, 3 (03) :578-590

[3] ANTIBACTERIAL ACTIVITY AND MUTAGENICITY STUDIES OF WATER-SOLUBLE PHOSPHAZENE HIGH POLYMERS [J].

ALLCOCK, HR ;

PUCHER, SR ;

FITZPATRICK, RJ ;

RASHID, K .

BIOMATERIALS, 1992, 13 (12) :857-862

[4] RECENT ADVANCES IN PHOSPHAZENE (PHOSPHONITRILIC) CHEMISTRY [J].

ALLCOCK, HR .

CHEMICAL REVIEWS, 1972, 72 (04) :315-&

[5]

[Anonymous], GLOB TUB REP

[6] Phosphorus-nitrogen compounds. Part 36. Syntheses, Langmuir-Blodgett thin films and biological activities of spiro-bino-spiro trimeric phosphazenes [J].

Asmafiliz, Nuran ;

Kilic, Zeynel ;

Civan, Mehmet ;

Avci, Orhan ;

Gonder, L. Yasemin ;

Acik, Leyla ;

Aydin, Betul ;

Turk, Mustafa ;

Hokelek, Tuncer .

NEW JOURNAL OF CHEMISTRY, 2016, 40 (11) :9609-9626

[7] New polymeric, dimeric and mononuclear dioxidomolybdenum(VI) complexes with an ONO donor ligand: crystal structures, DFT calculations, catalytic performance and protein binding study of the ligand [J].

Biswal, Debanjana ;

Pramanik, Nikhil Ranjan ;

Chakrabarti, Syamal ;

Drew, Michael G. B. ;

Sarkar, Bithika ;

Maurya, Mannar R. ;

Mukherjee, Sanjib K. ;

Chowdhury, Pramit .

NEW JOURNAL OF CHEMISTRY, 2017, 41 (10) :4116-4137

[8] Mannodendrimers prevent acute lung inflammation by inhibiting neutrophil recruitment [J].

Blattes, Emilyne ;

Vercellone, Alain ;

Eutamene, Helene ;

Turrin, Cedric-Olivier ;

Theodorou, Vassilia ;

Majoral, Jean-Pierre ;

Caminade, Anne-Marie ;

Prandi, Jacques ;

Nigou, Jerome ;

Puzo, Germain .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (22) :8795-8800

[9] Phosphorus dendrimers for nanomedicine [J].

Caminade, Anne-Marie .

CHEMICAL COMMUNICATIONS, 2017, 53 (71) :9830-9838

[10] The specific functionalization of cyclotriphosphazene for the synthesis of smart dendrimers [J].

Caminade, Anne-Marie ;

Hameau, Aurelien ;

Majoral, Jean-Pierre .

DALTON TRANSACTIONS, 2016, 45 (05) :1810-1822

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