DNA methylation landscapes: provocative insights from epigenomics

被引：2218

作者：

Suzuki, Miho M. ^{[1
]}

Bird, Adrian ^{[1
]}

机构：

[1] Univ Edinburgh, Wellcome Trust Ctr Cell Biol, Edinburgh EH9 3JR, Midlothian, Scotland

来源：

NATURE REVIEWS GENETICS | 2008年 / 9卷 / 06期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/nrg2341

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The genomes of many animals, plants and fungi are tagged by methylation of DNA cytosine. To understand the biological significance of this epigenetic mark it is essential to know where in the genome it is located. New techniques are making it easier to map DNA methylation patterns on a large scale and the results have already provided surprises. In particular, the conventional view that DNA methylation functions predominantly to irreversibly silence transcription is being challenged. Not only is promoter methylation often highly dynamic during development, but many organisms also seem to target DNA methylation specifically to the bodies of active genes.

引用

页码：465 / 476

页数：12

共 106 条

[61] DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development [J].

Okano, M ;

Bell, DW ;

Haber, DA ;

Li, E .

CELL, 1999, 99 (03) :247-257

[62] Maize genome sequencing by methylation filtrations [J].

Palmer, LE ;

Rabinowicz, PD ;

O'Shaughnessy, AL ;

Balija, VS ;

Nascimento, LU ;

Dike, S ;

de la Bastide, M ;

Martienssen, RA ;

McCombie, WR .

SCIENCE, 2003, 302 (5653) :2115-2117

[63] DNA hypomethylation can activate Xist expression and silence X-linked genes [J].

Panning, B ;

Jaenisch, R .

GENES & DEVELOPMENT, 1996, 10 (16) :1991-2002

[64] Human morbid genetics revisited: relevance of epigenetics [J].

Petronis, A .

TRENDS IN GENETICS, 2001, 17 (03) :142-146

[65] Differential methylation of genes and retrotransposons facilitates shotgun sequencing of the maize genome [J].

Rabinowicz, PD ;

Schutz, K ;

Dedhia, N ;

Yordan, C ;

Parnell, LD ;

Stein, L ;

McCombie, WR ;

Martienssen, RA .

NATURE GENETICS, 1999, 23 (03) :305-308

[66] Genes and transposons are differentially methylated in plants, but not in mammals [J].

Rabinowicz, PD ;

Palmer, LE ;

May, BP ;

Hemann, MT ;

Lowe, SW ;

McCombie, WR ;

Martienssen, RA .

GENOME RESEARCH, 2003, 13 (12) :2658-2664

[67] DNA methylation profiling of the human major histocompatibility complex: A pilot study for the Human Epigenome Project [J].

Rakyan, VK ;

Hildmann, T ;

Novik, KL ;

Lewin, J ;

Tost, J ;

Cox, AV ;

Andrews, TD ;

Howe, KL ;

Otto, T ;

Olek, A ;

Fischer, J ;

Gut, IG ;

Berlin, K ;

Beck, S .

PLOS BIOLOGY, 2004, 2 (12) :2170-2182

[68] High-resolution mapping of DNA hypermethylation and hypomethylation in lung cancer [J].

Rauch, Tibor A. ;

Zhong, Xueyan ;

Wu, Xiwei ;

Wang, Melody ;

Kernstine, Kemp H. ;

Wang, Zunde ;

Riggs, Arthur D. ;

Pfeifer, Gerd P. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (01) :252-257

[69] Genome-wide, high-resolution DNA methylation profiling using bisulfate-mediated cytosine conversion [J].

Reinders, Jon ;

Vivier, Celine Delucinge ;

Theiler, Gregory ;

Chollet, Didier ;

Descombes, Patrick ;

Paszkowski, Jerzy .

GENOME RESEARCH, 2008, 18 (03) :469-476

[70] EPIMUTATION OF REPEATED GENES IN ASCOBOLUS-IMMERSUS [J].

RHOUNIM, L ;

ROSSIGNOL, JL ;

FAUGERON, G .

EMBO JOURNAL, 1992, 11 (12) :4451-4457

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