Endothelial Progenitor Cells in Long-Standing Asymptomatic Type 1 Diabetic Patients with or without Diabetic Nephropathy

被引：7

作者：

Reinhard, Henrik ^{[1
]}

Jacobsen, Peter Karl ^{[1
,5
]}

Lajer, Maria ^{[1
]}

Tarnow, Lise ^{[1
]}

Astrup, Anne Sofie ^{[1
]}

Kim, Won Yong ^{[3
,4
]}

Pedersen, Nadja ^{[1
]}

Billestrup, Nils ^{[1
]}

Mandrup-Poulsen, Thomas ^{[2
,6
,9
]}

Parving, Hans-Henrik ^{[7
,8
]}

Rossing, Peter ^{[1
]}

机构：

[1] Steno Diabet Ctr, DK-2820 Gentofte, Denmark

[2] Hagedorn Res Inst, Dept Translat Diabetol, Gentofte, Denmark

[3] Skejby Hosp, Dept Cardiol, Skejby, Denmark

[4] Skejby Hosp, MR Ctr, Skejby, Denmark

[5] Rigshosp, Ctr Heart, DK-2100 Copenhagen, Denmark

[6] Univ Copenhagen, Dept Biomed Sci, Core Unit Med Res Methodol, Copenhagen, Denmark

[7] Univ Copenhagen Hosp, Rigshosp, Dept Med Endocrinol, DK-2100 Copenhagen, Denmark

[8] Aarhus Univ, Fac Hlth Sci, Aarhus, Denmark

[9] Karolinska Inst, Dept Med & Surg, Stockholm, Sweden

来源：

NEPHRON CLINICAL PRACTICE | 2011年 / 118卷 / 03期

关键词：

Cardiovascular disease; Diabetes mellitus; Diabetic nephropathy; Endothelial progenitor cells; CORONARY-ARTERY-DISEASE; ASYMMETRIC DIMETHYLARGININE; STATIN THERAPY; NITRIC-OXIDE; RISK-FACTORS; DYSFUNCTION; REENDOTHELIALIZATION; PROLIFERATION; ADHESION; INCREASE;

D O I：

10.1159/000322667

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

A decrease in the number and dysfunction of endothelial progenitor cells (EPC) may increase the risk for progression of cardiovascular disease (CVD) in type 1 diabetic patients with diabetic nephropathy (DN). Our aim was to evaluate EPC numbers in asymptomatic CVD type 1 diabetic patients with or without DN and to study the effect of CVD and medication on EPC numbers. Methods: We examined EPC numbers in 37 type 1 diabetic patients with DN and 35 type 1 diabetic patients with long-standing normoalbuminuria. Patients were without symptoms of CVD and the prevalence of CVD was previously shown to be very low. EPC number was assessed in in vitro cultures by fluorescent staining of attached cells. Results: There was no difference in EPC numbers between patients with DN (mean +/- SD 120 +/- 49 cells/field) and normoalbuminuria (108 +/- 41 cells/field; p = 0.25). Furthermore, EPC number was not associated with CVD (p > 0.05). Conventional risk factors were significantly higher in patients with DN and they received more CVD-preventive treatment. All patients receiving simvastatin or calcium-channel blockers had higher numbers of EPC compared to patients not treated with these drugs. Conclusions: Asymptomatic patients with DN had EPC numbers similar to normoalbuminuric patients, which was related to aggressive CVD intervention therapy. This may have contributed to the low prevalence of CVD. Copyright (C) 2011 S. Karger AG, Basel

引用

页码：C309 / C314

页数：6

共 29 条

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