The intertwined fates of inflammation and coagulation in glioma

被引：19
作者：
Cho, Angela [1 ,2 ,3 ]
McKelvey, Kelly J. [1 ,2 ,3 ]
Lee, Adrian [1 ,2 ,3 ]
Hudson, Amanda L. [1 ,2 ,3 ]
机构：
[1] Kolling Inst, Bill Walsh Translat Canc Res Lab, Brain Canc Grp, St Leonards, NSW 2065, Australia
[2] Northern Sydney Local Hlth Dist, St Leonards, NSW 2065, Australia
[3] Univ Sydney, Sydney Med Sch Northern, Camperdown, NSW 2065, Australia
来源：
MAMMALIAN GENOME | 2018年 / 29卷 / 11-12期
关键词：
MOLECULAR-WEIGHT HEPARIN; TISSUE FACTOR EXPRESSION; GROWTH-FACTOR RECEPTOR; FACTOR SIGNALING PATHWAY; VENOUS THROMBOEMBOLISM; PLASMINOGEN-ACTIVATOR; GLIOBLASTOMA-MULTIFORME; DEGRADATION PRODUCTS; RISK-FACTORS; TUMOR-CELLS;
D O I：
10.1007/s00335-018-9761-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Inflammation and coagulation are two intertwined pathways with evolutionary ties being traced back to the hemocyte, a single cell type in invertebrates that has functions in both the inflammatory and coagulation pathways. These systems have functioned together throughout evolution to provide a solid defence against infection, damaged cells and irritants. While these systems work in harmony the majority of the time, they can also become dysregulated or corrupted by tumours, enhancing tumour proliferation, invasion, dissemination and survival. This review aims to give a brief overview of how these systems work in harmony and how dysregulation of these systems aids in the development and progression of cancer, using glioma as an example.
引用
收藏
页码：806 / 816
页数：11
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