Spatial frequency threshold and contrast sensitivity of an optomotor behavior are impaired in the Ins2Akita mouse model of diabetes

被引：32

作者：

Akimov, Nikolay P.

Renteria, Rene C. ^{[1
]}

机构：

[1] Univ Texas Hlth Sci Ctr San Antonio, Dept Physiol, San Antonio, TX 78229 USA

来源：

BEHAVIOURAL BRAIN RESEARCH | 2012年 / 226卷 / 02期

关键词：

Diabetes; Diabetic retinopathy; Optokinetic response; Ins2(Akita) mouse; Vision; Retina; RETINAL GANGLION-CELLS; AMACRINE CELLS; RAT; VISION; SELECTIVITY; DYSFUNCTION; RETINOPATHY; NEUROPATHY; DYSTROPHY; MICE;

D O I：

10.1016/j.bbr.2011.09.030

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Diabetic retinopathy can lead to progressive loss of vision and is a leading cause of blindness. The Ins2(Akita) mouse model of diabetes develops significant retinal and systemic pathology, but how these affect visual behavior is unknown. Here, we show that Ins2(Akita) mice have progressive, quantifiable vision deficits in an optomotor behavior. This mouse line is a promising model in which to understand the contribution of retinal neuronal injury during the chronic hyperglycemia and hypoinsulinemia of diabetes to deficits in vision. (C) 2011 Elsevier B.V. All rights reserved.

引用

收藏

页码：601 / 605

页数：5

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