PARP family enzymes: regulation and catalysis of the poly(ADP-ribose) posttranslational modification

被引：136
作者：
Langelier, Marie-France [1 ]
Eisemann, Travis [1 ,2 ]
Riccio, Amanda A. [1 ,3 ]
Pascal, John M. [1 ]
机构：
[1] Univ Montreal, Dept Biochem & Mol Med, Montreal, PQ, Canada
[2] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA
[3] NIEHS, Durham, NC USA
来源：
CURRENT OPINION IN STRUCTURAL BIOLOGY | 2018年 / 53卷
关键词：
STERILE ALPHA-MOTIF; SINGLE-STRAND BREAKS; ADP-RIBOSYLATION; STRUCTURAL BASIS; ALLOSTERIC REGULATION; TANKYRASE; DOMAIN; POLYMERASE; POLYMERIZATION; MECHANISM;
D O I：
10.1016/j.sbi.2018.11.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Poly(ADP-ribose) is a posttranslational modification and signaling molecule that regulates many aspects of human cell biology, and it is synthesized by enzymes known as poly(ADP-ribose) polymerases, or PARPs. A diverse collection of domain structures dictates the different cellular roles of PARP enzymes and regulates the production of poly(ADP-ribose). Here we primarily review recent structural insights into the regulation and catalysis of two family members: PARP-1 and Tankyrase. PARP-1 has multiple roles in the cellular response to DNA damage and the regulation of gene transcription, and Tankyrase regulates a diverse set of target proteins involved in cellular processes such as mitosis, genome integrity, and cell signaling. Both enzymes offer interesting modes of regulating the production and the target site selectivity of the poly(ADP-ribose) modification.
引用
收藏
页码：187 / 198
页数：12
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