Protease sensing using nontoxic silicon quantum dots

被引：13

作者：

Cheng, Xiaoyu ^{[1
,2
]}

McVey, Benjamin F. P. ^{[1
]}

Robinson, Andrew B. ^{[1
]}

Longatte, Guillaume ^{[1
]}

O'Mara, Peter B. ^{[1
]}

Tan, Vincent T. G. ^{[1
]}

Thordarson, Pall ^{[1
]}

Tilley, Richard D. ^{[1
]}

Gaus, Katharina ^{[2
]}

Gooding, John Justin ^{[1
]}

机构：

[1] Univ New South Wales, Sch Chem, Australian Ctr NanoMed, ARC Ctr Excellence Convergent Bionano Sci & Techn, Sydney, NSW, Australia

[2] Univ New South Wales, EMBL Australia Node Single Mol Sci, Sch Med Sci, ARC Ctr Excellence Adv Mol Imaging, Sydney, NSW, Australia

来源：

JOURNAL OF BIOMEDICAL OPTICS | 2017年 / 22卷 / 08期

基金：

英国医学研究理事会; 澳大利亚研究理事会;

关键词：

quantum dots; silicon; biosensor; Forster resonance energy transfer; self-assembled monolayer; ENERGY-TRANSFER; NANOPARTICLES; FLUORESCENT; NANOCRYSTALS; PHOTOLUMINESCENCE; SIZE; LUMINESCENCE; CHEMISTRY;

D O I：

10.1117/1.JBO.22.8.087002

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Herein is presented a proof-of-concept study of protease sensing that combines nontoxic silicon quantum dots (SiQDs) with Forster resonance energy transfer (FRET). The SiQDs serve as the donor and an organic dye as the acceptor. The dye is covalently attached to the SiQDs using a peptide linker. Enzymatic cleavage of the peptide leads to changes in FRET efficiency. The combination of interfacial design and optical imaging presented in this work opens opportunities for use of nontoxic SiQDs relevant to intracellular sensing and imaging. (C) 2017 Society of Photo-Optical Instrumentation Engineers (SPIE)

引用

页数：7

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