Thymic Adenocarcinoma with Positivity for Thyroid Transcription Factor-1 and a BRAF V600E Mutation

被引：0
作者：
Yorozuya, Takafumi [1 ]
Otsuka, Mitsuo [1 ]
Ichihara, Shin [2 ]
Fujimori, Kento [1 ]
Kitamura, Chikako [1 ]
Takahashi, Tomoyuki [1 ]
Mori, Masaki [1 ]
Cho, Yasushi [3 ]
Chiba, Hirofumi [4 ]
机构：
[1] Sapporo Kosei Gen Hosp, Dept Resp Med, Sapporo, Hokkaido, Japan
[2] Sapporo Kosei Gen Hosp, Dept Surg Pathol, Sapporo, Hokkaido, Japan
[3] Sapporo Kosei Gen Hosp, Dept Surg, Sapporo, Hokkaido, Japan
[4] Sapporo Med Univ, Dept Resp Med & Allergol, Sch Med, Sapporo, Hokkaido, Japan
来源：
INTERNAL MEDICINE | 2022年 / 61卷 / 03期
关键词：
thymus; thymic carcinoma; thymic adenocarcinoma; BRAF V600E; thyroid transcription factor-1; PHASE-II; POSTOPERATIVE RADIOTHERAPY; INVASIVE THYMOMA; UNKNOWN PRIMARY; SINGLE-ARM; CARCINOMA; CANCER; CARBOPLATIN; MULTICENTER; PACLITAXEL;
D O I：
10.2169/internalmedicine.7623-21
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Thymic adenocarcinomas are rare. We herein report for the first time a case of thymic adenocarcinoma with positivity for thyroid transcription factor-1 (TTF-1) and a BRAF V600E mutation. A 50-year-old woman had persistent suffocation and chest pain. Computed tomography revealed a 42x28-mm tumor in the anterior mediastinum. The patient underwent tumor resection using video-assisted thoracoscopic surgery. Histopathological findings showed thymic papillary adenocarcinoma, Masaoka stage II. Immunohistochemically, the tumor was positive for TTF-1. A sequencing analysis revealed a BRAF V600E mutation. The patient underwent postoperative radiotherapy and was in good health without recurrence at five months after resection.
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收藏
页码：385 / 388
页数：4
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