Poly(lactic-co-glycolic acid) nanomaterial-based treatment options for pain management: a review

被引：14

作者：

Phaam, Thuy Linh ^{[1
,2
,3
]}

Kim, Dong Woon ^{[1
,2
]}

机构：

[1] Chungnam Natl Univ, Coll Med, Dept Med Sci, Daejeon 35015, South Korea

[2] Chungnam Natl Univ, Coll Med, Brain Res Inst, Dept Anat, Daejeon 35015, South Korea

[3] Hai Phong Univ Med & Pharm Hosp, Dept Histol & Embryol, Hai Phong 04212, Vietnam

来源：

NANOMEDICINE | 2020年 / 15卷 / 19期

基金：

新加坡国家研究基金会;

关键词：

nanomaterials; nanomedicine; neuropathic pain; neuropathic pain management; PLGA nanoparticles; therapeutics; ATTENUATES NEUROPATHIC PAIN; FACTOR-KAPPA-B; PLGA NANOPARTICLES; GENE-THERAPY; SPINAL-CORD; DELIVERY-SYSTEMS; LIPID NANOPARTICLES; SIGNALING PATHWAYS; DORSAL-HORN; MECHANISMS;

D O I：

10.2217/nnm-2020-0114

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Neuropathic pain is one of the most intense types of chronic pain; it constitutes a pervasive complaint throughout the public health system. With few effective treatments, it remains a significant challenge. Commercially available drugs for neuropathic pain are still limited and have disappointing efficacy. Therefore, chronic neuropathic pain imposes a tremendous burden on patients' quality of life. Recently, the introduction and application of nanotechnology in multiple fields has accelerated the development of new drugs. This review highlights the application of poly(lactic-co-glycolic acid) nanomaterial-based vehicles for drug delivery and how they improve the therapeutic outcomes for neuropathic pain treatment. Finally, future developments for pain research and effective management are presented.

引用

页码：1897 / 1913

页数：17

共 145 条

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