Dynamin, a membrane-remodelling GTPase

被引：736
作者：
Ferguson, Shawn M. [1 ,2 ]
De Camilli, Pietro [1 ,2 ,3 ,4 ]
机构：
[1] Yale Univ, Sch Med, Dept Cell Biol, New Haven, CT 06510 USA
[2] Yale Univ, Sch Med, Program Cellular Neurosci Neurodegenerat & Repair, New Haven, CT 06510 USA
[3] Yale Univ, Sch Med, Kavli Inst Neurosci, New Haven, CT 06510 USA
[4] Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06510 USA
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2012年 / 13卷 / 02期
基金：
美国国家卫生研究院;
关键词：
CLATHRIN-COATED PITS; PLECKSTRIN HOMOLOGY DOMAIN; RECEPTOR-MEDIATED ENDOCYTOSIS; ACTIN CYTOSKELETON; MECHANOCHEMICAL ENZYME; STRUCTURAL BASIS; MOLECULAR-MECHANISM; AMPHIPHYSIN-2; BIN1; VESICLE FORMATION; HOMOTYPIC FUSION;
D O I：
10.1038/nrm3266
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Dynamin, the founding member of a family of dynamin-like proteins (DLPs) implicated in membrane remodelling, has a critical role in endocytic membrane fission events. The use of complementary approaches, including live-cell imaging, cell-free studies, X-ray crystallography and genetic studies in mice, has greatly advanced our understanding of the mechanisms by which dynamin acts, its essential roles in cell physiology and the specific function of different dynamin isoforms. In addition, several connections between dynamin and human disease have also emerged, highlighting specific contributions of this GTPase to the physiology of different tissues.
引用
收藏
页码：75 / 88
页数：14
相关论文
共 194 条
  • [141] Real-Time Visualization of Dynamin-Catalyzed Membrane Fission and Vesicle Release
    Pucadyil, Thomas J.
    Schmid, Sandra L.
    [J]. CELL, 2008, 135 (07) : 1263 - 1275
  • [142] Overlapping Role of Dynamin Isoforms in Synaptic Vesicle Endocytosis
    Raimondi, Andrea
    Ferguson, Shawn M.
    Lou, Xuelin
    Armbruster, Moritz
    Paradise, Summer
    Giovedi, Silvia
    Messa, Mirko
    Kono, Nao
    Takasaki, Junko
    Cappello, Valentina
    O'Toole, Eileen
    Ryan, Timothy A.
    De Camilli, Pietro
    [J]. NEURON, 2011, 70 (06) : 1100 - 1114
  • [143] The dynamin middle domain is critical for tetramerization and higher-order self-assembly
    Ramachandran, Rajesh
    Surka, Mark
    Chappie, Joshua S.
    Fowler, Douglas M.
    Foss, Ted R.
    Song, Byeong Doo
    Schmid, Sandra L.
    [J]. EMBO JOURNAL, 2007, 26 (02) : 559 - 566
  • [144] Membrane Insertion of the Pleckstrin Homology Domain Variable Loop 1 Is Critical for Dynamin-catalyzed Vesicle Scission
    Ramachandran, Rajesh
    Pucadyil, Thomas J.
    Liu, Ya-Wen
    Acharya, Sharmistha
    Leonard, Marilyn
    Lukiyanchuk, Vasyl
    Schmid, Sandra L.
    [J]. MOLECULAR BIOLOGY OF THE CELL, 2009, 20 (22) : 4630 - 4639
  • [145] Molecular basis for SH3 domain regulation of F-BAR-mediated membrane deformation
    Rao, Yijian
    Ma, Qingjun
    Vahedi-Faridi, Ardeschir
    Sundborger, Anna
    Pechstein, Arndt
    Puchkov, Dmytro
    Luo, Lin
    Shupliakov, Oleg
    Saenger, Wolfram
    Haucke, Volker
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (18) : 8213 - 8218
  • [146] A PUTATIVE GTP BINDING-PROTEIN HOMOLOGOUS TO INTERFERON-INDUCIBLE MX PROTEINS PERFORMS AN ESSENTIAL FUNCTION IN YEAST PROTEIN SORTING
    ROTHMAN, JH
    RAYMOND, CK
    GILBERT, T
    OHARA, PJ
    STEVENS, TH
    [J]. CELL, 1990, 61 (06) : 1063 - 1074
  • [147] GTP-dependent twisting of dynamin implicates constriction and tension in membrane fission
    Roux, Aurelien
    Uyhazi, Katherine
    Frost, Adam
    De Camilli, Pietro
    [J]. NATURE, 2006, 441 (7092) : 528 - 531
  • [148] Membrane curvature controls dynamin polymerization
    Roux, Aurelien
    Koster, Gerbrand
    Lenz, Martin
    Sorre, Benoit
    Manneville, Jean-Baptiste
    Nassoy, Pierre
    Bassereau, Patricia
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (09) : 4141 - 4146
  • [149] Distinct Dynamics of Endocytic Clathrin-Coated Pits and Coated Plaques
    Saffarian, Saveez
    Cocucci, Emanuele
    Kirchhausen, Tomas
    [J]. PLOS BIOLOGY, 2009, 7 (09)
  • [150] Modulation of Rac localization and function by dynamin
    Schlunck, G
    Damke, H
    Kiosses, WB
    Rusk, N
    Symons, MH
    Waterman-Storer, CM
    Schmid, SL
    Schwartz, MA
    [J]. MOLECULAR BIOLOGY OF THE CELL, 2004, 15 (01) : 256 - 267
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