Nitric oxide-cyclic GMP signaling in stem cell differentiation

被引：38
作者：
Mujoo, Kalpana [1 ]
Krumenacker, Joshua S. [2 ]
Murad, Fend [3 ]
机构：
[1] Univ Texas Hlth Sci Ctr Houston, Brown Fdn Inst Mol Med, Texas Therapeut Inst, Houston, TX 77030 USA
[2] Indiana Univ Sch Med, Dept Family Med, Indianapolis, IN 46202 USA
[3] George Washington Univ, Dept Biochem & Mol Biol, Washington, DC 20037 USA
来源：
FREE RADICAL BIOLOGY AND MEDICINE | 2011年 / 51卷 / 12期
基金：
美国国家卫生研究院;
关键词：
Nitric oxide; Cyclic GMP; Stem cells; Differentiation; Free radicals; SOLUBLE GUANYLYL CYCLASE; DEPENDENT PROTEIN-KINASE; ATRIAL-NATRIURETIC-PEPTIDE; MICE LACKING; CARDIAC-FUNCTION; GENE-EXPRESSION; NUCLEOTIDE PHOSPHODIESTERASES; REPERFUSION INJURY; MOLECULAR-CLONING; HUMAN FIBROBLASTS;
D O I：
10.1016/j.freeradbiomed.2011.09.037
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The nitric oxide-cyclic GMP (NO-cGMP) pathway mediates important physiological functions associated with various integrative body systems including the cardiovascular and nervous systems. Furthermore, NO regulates cell growth, survival, apoptosis, proliferation, and differentiation at the cellular level. To understand the significance of the NO-cGMP pathway in development and differentiation, studies have been conducted both in developing embryos and in stem cells. Manipulation of the NO-cGMP pathway, by employing activators and inhibitors as pharmacological probes, and genetic manipulation of NO signaling components have implicated the involvement of this pathway in the regulation of stem cell differentiation. This review focuses on some of the work pertaining to the role of NO-cGMP in the differentiation of stem cells into cells of various lineages, particularly into myocardial cells, and in stem cell-based therapy. Published by Elsevier Inc.
引用
收藏
页码：2150 / 2157
页数：8
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