Lignans with neuroprotective activity from the fruits of Crataegus pinnatifida

被引：7

作者：

Xin, Ben-Song ^{[1
]}

Zhao, Peng ^{[1
]}

Qin, Shu-Yan ^{[1
]}

Yao, Guo-Dong ^{[1
]}

Huang, Xiao-Xiao ^{[1
]}

Song, Shao-jiang ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Engn Res Ctr Nat Med Act Mol Res & Dev, Sch Tradit Chinese Mat Med,Key Lab Nat Bioact Cpd, Key Lab Computat Chem Based Nat Antitumor Drug Re, Shenyang 110016, Liaoning, Peoples R China

来源：

FITOTERAPIA | 2022年 / 160卷

关键词：

Crataegus pinnatifida; Lignans; Chiral resolution; Enantiomers; Bioinformatics analysis; Neuroprotective activities; CHEMICAL-CONSTITUENTS; HAWTHORN; NEOLIGNANS; LEAVES; ENANTIOMERS; GLYCOSIDES;

D O I：

10.1016/j.fitote.2022.105216

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Seven lignans (1a/1b-2a/2b and 3-5), including six new compounds (1b, 2a/2b, 3-5), were isolated from the fruits of Crataegus pinnatifida. Their structures were elucidated by comprehensive spectroscopic analyses. Compounds 1b/1b-2a/2b were two pairs of enantiomers and the absolute configurations were determined by comparison of their experimental and calculated ECD spectra. Moreover, bioinformatics analysis suggested that more than a third of diseases were related to the nervous system. Therefore, all compounds were evaluated for neuroprotective effects toward human neumblastoma SH-SY5Y cells injury induced by H2O2. Among them, compound la exhibited moderate protective effect.

引用

页数：9

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