Synthesis and SAR of 2- and 3-substituted 7-azaindoles as potential dopamine D4 ligands

被引：46

作者：

Curtis, NR

Kulagowski, JJ

Leeson, PD

Ridgill, MP

Emms, F

Freedman, SB

Patel, S

Patel, S

机构：

[1] Merck Sharp & Dohme Res Labs, Ctr Res Neurosci, Dept Med Chem, Harlow CM20 2QR, Essex, England

[2] Merck Sharp & Dohme Res Labs, Ctr Res Neurosci, Dept Biochem, Harlow CM20 2QR, Essex, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(99)00025-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

7-azaindole compounds bearing a cyclic amine moiety linked by a one or two carbon chain attached at the 2- or 3-position were synthesised and evaluated as potential dopamine D-4 ligands. Highest affinity and selectivity for the D-4 receptor resided in the 3-aminomethyl-7-azaindole series. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：585 / 588

页数：4

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