Association of the Methylenetetrahydrofolate Reductase Gene A1298C Polymorphism with Male Infertility: A Meta-Analysis

被引:24
作者
Shen, Ouxi [2 ]
Liu, Renping [2 ]
Wu, Wei [1 ]
Yu, Lugang [2 ]
Wang, Xinru [1 ,3 ]
机构
[1] Nanjing Med Univ, Inst Toxicol, State Key Lab Reprod Med, Nanjing 210029, Jiangsu, Peoples R China
[2] Ctr Dis Control & Prevent Suzhou Ind Pk, Suzhou 215021, Peoples R China
[3] Nanjing Med Univ, Sch Publ Hlth, Key Lab Modern Toxicol, Minist Educ, Nanjing 210029, Jiangsu, Peoples R China
基金
中国国家自然科学基金;
关键词
Methylenetetrahydrofolate reductase; MTHFR; polymorphism; male infertility; meta-analysis; IDIOPATHIC MALE-INFERTILITY; DNA METHYLATION; COMMON MUTATION; RISK-FACTOR; FOLIC-ACID; MTHFR; METABOLISM; C677T; MICE; MEN;
D O I
10.1111/j.1469-1809.2011.00691.x
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Published data on the association between the methylenetetrahydrofolate reductase (MTHFR) gene A1298C (rs1801131) polymorphism and male infertility risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. In this meta-analysis, a total of seven case-control studies including 1633 cases and 1735 controls were selected to evaluate the possible association. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association in the additive model, dominant model, recessive model, and allele-frequency genetic model. In the overall analysis, the frequency of the C1298 allele (C vs. A) was significantly associated with susceptibility to male infertility (OR = 1.12, 95% CI = 1.001.26). A subgroup analysis of the subjects showed that MTHFR 1298C was associated with significant increased risk of azoospermia in homozygote comparison (CC vs. AA) and recessive mode (CC vs. AA/AC) (OR = 1.66 for CC vs. AA genotype; OR = 1.67 for CC vs. AA/AC genotype). However, no statistically significant increased risk of oligoasthenoteratozoospermia was found in any of the genetic models. In conclusion, this meta-analysis supports that the MTHFR A1298C polymorphism is capable of causing male infertility susceptibility, especially azoospermia.
引用
收藏
页码:25 / 32
页数:8
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