Iron therapy as a novel treatment of scleroderma-related pulmonary hypertension: A case report and literature review

被引：3

作者：

Neumann, Melissa ^{[1
]}

Wong, Karen A. ^{[2
]}

Lazo, Kevin ^{[2
]}

Stover, Diane ^{[2
]}

机构：

[1] Northwell Hlth, Dept Med, 300 Community Dr, Manhasset, NY 11020 USA

[2] Mem Sloan Kettering Canc Ctr, Pulm Serv, New York, NY USA

来源：

RESPIROLOGY CASE REPORTS | 2022年 / 10卷 / 02期

关键词：

iron therapy; pulmonary arterial hypertension; pulmonary hypertension; scleroderma; systemic sclerosis; ARTERIAL-HYPERTENSION; DEFICIENCY;

D O I：

10.1002/rcr2.904

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Pulmonary arterial hypertension (PAH) is the leading cause of death in patients with systemic sclerosis (SSc), with a 3-year mortality of 40%-50% despite optimal therapy. Treatment mirrors that of idiopathic PAH and is often ineffective. This is a case report of a patient with SSc evaluated for progressive dyspnoea with exertion and found to have elevated pulmonary artery systolic pressures (PASPs). She received ferritin-targeted iron infusions as a novel treatment of suspected SSc-associated PAH, with subsequent resolution of respiratory symptoms and PASPs that normalized. We review PAH especially associated with SSc, its treatment and identify a possible novel therapeutic approach for those with PAH-SSc.

引用

页数：4

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