Micelles from Amphiphilic Block Copolyphosphates for Drug Delivery

被引：32

作者：

Zhai, Xiang ^{[1
]}

Huang, Wei ^{[1
]}

Liu, Jinyao ^{[1
]}

Pang, Yan ^{[1
]}

Zhu, Xinyuan ^{[1
]}

Zhou, Yongfeng ^{[1
]}

Yan, Deyue ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, State Key Lab Met Matrix Composites, Shanghai 200240, Peoples R China

来源：

MACROMOLECULAR BIOSCIENCE | 2011年 / 11卷 / 11期

基金：

中国国家自然科学基金;

关键词：

amphiphilic; block copolyphosphates; drug delivery systems; drug release; micelles; SELF-ASSEMBLED MICELLES; TRIBLOCK COPOLYMERS; POLYMERIC MICELLES; CANCER-THERAPY; POLYPHOSPHOESTER; RELEASE; DESIGN; TRANSPORT; KINETICS; TISSUE;

D O I：

10.1002/mabi.201100163

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Amphiphilic block copolyphosphates (PEP-b-PIPPs) are synthesized by two-step ROP of cyclic phosphate monomers with different pedant groups. They can spontaneously self-assemble into approximately spherical micelles ranging in size between 89 and 198nm in water. A typical hydrophobic anti-cancer drug DOX is encapsulated into the micelles. The release rate of DOX slows down with increasing hydrophobic block length of PIPP. DOX-loaded micelles are investigated for the proliferation inhibition of Hela cells and the DOX dose required for 50% cellular growth inhibition is found to be 0.8 mu gmL(-1). It is demonstrated that PEP-b-PIPP micelles can be used as a safe and promising drug delivery system.

引用

页码：1603 / 1610

页数：8

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