6-Oxocytidine containing oligonucleotides inhibit the HIV-1 integrase in vitro

被引：8

作者：

Brodin, P

Pinskaya, M

Parsch, U

Bischerour, J

Leh, H

Romanova, E

Engels, JW

Gottikh, M

Mouscadet, JF

机构：

[1] Inst Gustave Roussy, UMR 8532, F-94805 Villejuif, France

[2] Moscow MV Lomonosov State Univ, Belozersky Inst Physicochem Biol, Moscow 119899, Russia

[3] Univ Frankfurt, Inst Organ Chem, D-60439 Frankfurt, Germany

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2001年 / 20卷 / 4-7期

关键词：

D O I：

10.1081/NCN-100002322

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Integration of the proviral DNA into the genome of infected cells is a key step of HIV-1 replication. Integration is catalyzed by the viral enzyme integrase (IN). 6-oxocytidine-containing oligonucleotides were found to be efficient inhibitors of integrase in vitro. The inhibitory effect is sequence-specific and strictly requires the presence of the 6-oxocytidine base. It is due to the impairment of the integrase binding to its substrate and does not involve an auto-structure of the oligonucleotide.

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页码：481 / 486

页数：6

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