Practical demethylation of aryl methyl ethers using an odorless thiol reagent

被引：43

作者：

Chae, Junghyun ^{[1
,2
]}

机构：

[1] Sungshin Womens Univ, Dept Chem, Seoul 136742, South Korea

[2] Sungshin Womens Univ, Inst Basic Sci, Seoul 136742, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2008年 / 31卷 / 03期

关键词：

demethylation; aryl methyl ether; long-chain thiol; in-situ generation of alkylthiolate;

D O I：

10.1007/s00000-001-1156-y

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A highly practical method for demethylation of aryl methyl ethers employing a long-chain thiol has been developed. Under the conditions described herein, clean and fast conversions to the desired phenolic compounds have been achieved with a broad range of substrates. Unlike other thiolate-mediated methods, this newly developed protocol features in-situ generation of sodium alkylthiolate using NaOH, and is almost free from foul smells and potentially harmful gases. It therefore provides an attractive option for the demethylation of aryl methyl ethers.

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收藏

页码：305 / 309

页数：5

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